Evidence map›Paper›PMID 38399975›Full record

ArticleViruses2024

Comparison between the Viral Illness Caused by SARS-CoV-2, Influenza Virus, Respiratory Syncytial Virus and Other Respiratory Viruses in Pediatrics.

Giulia Brigadoi, Giulia Camilla Demarin, Riccardo Boracchini, Luca Pierantoni, Sara Rossin, Elisa Barbieri, Francesca Tirelli, Anna Cantarutti, Gaia Tempo, Carlo Giaquinto and 3 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Giulia BrigadoiDivision of Pediatric Infectious Diseases, Department for Women's and Children's Health, University of Padua, 35128 Padua, Italy.ORCID 0009-0004-0600-7745
Giulia Camilla DemarinDivision of Pediatric Infectious Diseases, Department for Women's and Children's Health, University of Padua, 35128 Padua, Italy.
Riccardo BoracchiniLaboratory of Healthcare Research & Pharmacoepidemiology, Unit of Biostatistics, Epidemiology and Public Health, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, 20126 Milan, Italy.ORCID 0009-0002-8339-9485
Luca PierantoniPediatric Emergency Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.ORCID 0000-0001-8175-5488
Sara RossinPediatric Emergency Department, Department of Women's and Children's Health, University of Padua, 35128 Padua, Italy.
Elisa BarbieriDivision of Pediatric Infectious Diseases, Department for Women's and Children's Health, University of Padua, 35128 Padua, Italy.ORCID 0000-0003-0850-8784
Francesca TirelliPediatric Emergency Department, Department of Women's and Children's Health, University of Padua, 35128 Padua, Italy.
Anna CantaruttiLaboratory of Healthcare Research & Pharmacoepidemiology, Unit of Biostatistics, Epidemiology and Public Health, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, 20126 Milan, Italy.ORCID 0000-0002-3700-780X
Gaia TempoDepartment of Anesthesia and Intensive Care, Fondazione Policlinico Universitario "A Gemelli" IRCCS, 00168 Rome, Italy.
Carlo GiaquintoDivision of Pediatric Infectious Diseases, Department for Women's and Children's Health, University of Padua, 35128 Padua, Italy.
Marcello LanariPediatric Emergency Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
Liviana Da DaltPediatric Emergency Department, Department of Women's and Children's Health, University of Padua, 35128 Padua, Italy.ORCID 0000-0003-2977-3907
Daniele DonàDivision of Pediatric Infectious Diseases, Department for Women's and Children's Health, University of Padua, 35128 Padua, Italy.ORCID 0000-0001-7105-2105
University of Padua · ITAzienda USL di Bologna · ITUniversity of Milano-Bicocca · ITAgostino Gemelli University Polyclinic · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Respiratory tract infections (RTIs) are the most common infectious syndromes, primarily caused by viruses. The primary objective was to compare the illness courses between historical RTIs and recent SARS-CoV-2 infections. The study cohort consisted of RTI cases evaluated at the Pediatric Emergency Departments of Padua and Bologna, discharged or admitted with microbiologically confirmed viral RTI between 1 November 2018 and 30 April 2019 (historical period) and 1 March 2020 and 30 April 2021 (recent period). We evaluated the risk of oxygen or respiratory support, hospitalization, antibiotic therapy, and complications among different viral infections. The odds ratio (OR) and the 95% confidence intervals (CIs) were estimated through mixed-effect logistic regression models, including a random intercept on the individual and hospital. We identified 767 RTIs: 359 in the historical period compared with 408 SARS-CoV-2 infections. Infections of SARS-CoV-2 had a lower risk of being admitted (OR 0.04, 95% CI 0.03-0.07), receiving respiratory support (OR 0.19, 95% CI 0.06-0.58), needing antibiotic therapy (OR 0.35, 95% CI 0.22-0.56) and developing complications (OR 0.27, 95% CI 0.14-0.51) compared to all other viral RTIs. COVID-19 in children is clinically similar to other viral RTIs but is associated with a less severe infection course. Thus, most prevention strategies implemented for SARS-CoV-2 should still be considered during RSV and Influenza epidemics.

Indexed as

COVID-19Influenza, HumanOrthomyxoviridaeRespiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsRespiratory Tract InfectionsVirus DiseasesVirusesAnti-Bacterial AgentsChildHumansSARS-CoV-2Anti-Bacterial AgentschildrenCOVID-19Influenza viruspediatricrespiratory syncytial virusrespiratory tract infectionsSARS-CoV-2

Identifiers

PMID38399975
PMCPMC10891516
OpenAlexW4391315545

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.