Evidence map›Paper›PMID 38399876›Full record

ArticlePolymers2024

Three-Dimensional Bioprinting of Strontium-Modified Controlled Assembly of Collagen Polylactic Acid Composite Scaffold for Bone Repair.

Weiwei Sun, Wenyu Xie, Kun Hu, Zongwen Yang, Lu Han, Luhai Li, Yuansheng Qi, Yen Wei

Open access · goldAbstract read
In one paragraph

Article in Polymers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Weiwei SunBeijing Engineering Research Center of Printed Electronics, Institute of Printing and Packaging Engineering, Beijing Institute of Graphic Communication, Beijing 102600, China.ORCID 0000-0003-2541-7980
Wenyu XieBeijing Engineering Research Center of Printed Electronics, Institute of Printing and Packaging Engineering, Beijing Institute of Graphic Communication, Beijing 102600, China.
Kun HuBeijing Engineering Research Center of Printed Electronics, Institute of Printing and Packaging Engineering, Beijing Institute of Graphic Communication, Beijing 102600, China.
Zongwen YangBeijing Engineering Research Center of Printed Electronics, Institute of Printing and Packaging Engineering, Beijing Institute of Graphic Communication, Beijing 102600, China.
Lu HanBeijing Engineering Research Center of Printed Electronics, Institute of Printing and Packaging Engineering, Beijing Institute of Graphic Communication, Beijing 102600, China.
Luhai LiBeijing Engineering Research Center of Printed Electronics, Institute of Printing and Packaging Engineering, Beijing Institute of Graphic Communication, Beijing 102600, China.
Yuansheng QiBeijing Engineering Research Center of Printed Electronics, Institute of Printing and Packaging Engineering, Beijing Institute of Graphic Communication, Beijing 102600, China.
Yen WeiDepartment of Chemistry, Tsinghua University, Beijing 100084, China.
Beijing Institute of Graphic Communication · CNSoochow University · CNTsinghua University · CN

Funding

Beijing Institute of Graphic Communication R&D Project "Research on Pressure Sensing Anti-bacterial Polyester Urethral Stent " Ee202207National Key Research and Development Program of China "Research on Key Technologies and Product Development of Border Personal Physical Protection Products" 2022YFC2305005
6 · The paper itself

Abstract

In recent years, the incidence of bone defects has been increasing year by year. Bone transplantation has become the most needed surgery after a blood transfusion and shows a rising trend. Three-dimensional-printed implants can be arbitrarily shaped according to the defects of tissues and organs to achieve perfect morphological repair, opening a new way for non-traumatic repair and functional reconstruction. In this paper, strontium-doped mineralized collagen was first prepared by an in vitro biomimetic mineralization method and then polylactic acid was homogeneously blended with the mineralized collagen to produce a comprehensive bone repair scaffold by a gas extrusion 3D printing method. Characterization through scanning electron microscopy, X-ray diffraction, and mechanical testing revealed that the strontium-functionalized composite scaffold exhibits an inorganic composition and nanostructure akin to those of human bone tissue. The scaffold possesses uniformly distributed and interconnected pores, with a compressive strength reaching 21.04 MPa. The strontium doping in the mineralized collagen improved the biocompatibility of the scaffold and inhibited the differentiation of osteoclasts to promote bone regeneration. This innovative composite scaffold holds significant promise in the field of bone tissue engineering, providing a forward-thinking solution for prospective bone injury repair.

Indexed as

3D bioprintingbone tissue engineeringcontrolled assemblymineralized collagenPLA

Identifiers

PMID38399876
PMCPMC10891933
OpenAlexW4391753156

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.