Evidence map›Paper›PMID 38399513›Full record

ReviewMedicina (Kaunas, Lithuania)2024

Perimyocarditis Associated with Immune Checkpoint Inhibitors: A Case Report and Review of the Literature.

Walid Shalata, Rachel Steckbeck, Amjad Abu Salman, Omar Abu Saleh, Ashraf Abu Jama, Zoé Gabrielle Attal, Sondos Shalata, Hilmi Alnsasra, Alexander Yakobson

Open access · goldAbstract readCase ReportsReview
In one paragraph

Review in Medicina (Kaunas, Lithuania), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Comprehensive analysis ofJournal of thoracic disease · 2026
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Walid ShalataThe Legacy Heritage Oncology Center and Dr. Larry Norton Institute, Soroka Medical Center & Ben-Gurion University, Beer-Sheva 84105, Israel.ORCID 0000-0002-7570-4550
Rachel SteckbeckMedical School for International Health and Sciences, Ben-Gurion University, Beer-Sheva 84105, Israel.
Amjad Abu SalmanCardiology Department, Soroka Medical Center & Ben-Gurion University, Beer-Sheva 84105, Israel.
Omar Abu SalehDepartment of Dermatology and Venereology, Emek Medical Centre, Afula 18341, Israel.
Ashraf Abu JamaThe Legacy Heritage Oncology Center and Dr. Larry Norton Institute, Soroka Medical Center & Ben-Gurion University, Beer-Sheva 84105, Israel.
Zoé Gabrielle AttalMedical School for International Health and Sciences, Ben-Gurion University, Beer-Sheva 84105, Israel.ORCID 0009-0006-9382-611X
Sondos ShalataNutrition Unit, Galilee Medical Center, Nahariya 22000, Israel.
Hilmi AlnsasraCardiology Department, Soroka Medical Center & Ben-Gurion University, Beer-Sheva 84105, Israel.
Alexander YakobsonThe Legacy Heritage Oncology Center and Dr. Larry Norton Institute, Soroka Medical Center & Ben-Gurion University, Beer-Sheva 84105, Israel.
Soroka Medical Center · ILBen-Gurion University of the Negev · ILEmek Medical Center · ILWestern Galilee Hospital · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patient prognoses have been significantly enhanced by immune checkpoint inhibitors (ICIs), altering the standard of care in cancer treatment. These novel antibodies have become a mainstay of care for metastatic non-small-cell lung cancer (mNSCLC) patients. Several types of adverse events related to ICIs have been identified and documented as a result of the launch of these innovative medicines. We present here a 74-year-old female patient with a stage IV lung adenocarcinoma, treated with nivolumab plus ipilimumab, who developed perimyocarditis two weeks after receiving the third cycle of immune checkpoint inhibitor therapy. The patient was diagnosed using troponin levels, computed tomography (CT) angiography, and echocardiography. After hospitalization, her cardiac condition was successfully resolved with corticosteroids, colchicine, and symptomatic treatment. To the best of our knowledge, this is one of the rarest cases to be reported of perimyocarditis as a toxicity of immunotherapy in a patient treated for adenocarcinoma of the lung.

Indexed as

Antineoplastic Agents, ImmunologicalCarcinoma, Non-Small-Cell LungLung NeoplasmsAgedFemaleHumansImmune Checkpoint InhibitorsIpilimumabNivolumabAntineoplastic Agents, ImmunologicalImmune Checkpoint InhibitorsIpilimumabNivolumabimmune checkpoint inhibitor (ICIs)lung cancermyocarditisOpdivo® (nivolumab)pericarditisperimyocarditisYervoy® (ipilimumab)

Identifiers

PMID38399513
PMCPMC10890382
OpenAlexW4391311625

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.