Evidence map›Paper›PMID 38399425›Full record

ReviewPharmaceuticals (Basel, Switzerland)2024

Integrating Artificial Intelligence and PET Imaging for Drug Discovery: A Paradigm Shift in Immunotherapy.

Jeremy P McGale, Harrison J Howell, Arnaud Beddok, Mickael Tordjman, Roger Sun, Delphine Chen, Anna M Wu, Tarek Assi, Samy Ammari, Laurent Dercle

Abstract readReview
In one paragraph

Review in Pharmaceuticals (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jeremy P McGaleDepartment of Radiology, New York-Presbyterian Hospital, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.
Harrison J HowellDepartment of Radiology, New York-Presbyterian Hospital, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.
Arnaud BeddokDepartment of Radiation Oncology, Institut Godinot, 51100 Reims, France.ORCID 0000-0002-5512-4161
Mickael TordjmanDepartment of Radiology, Hôtel Dieu Hospital, APHP, 75014 Paris, France.
Roger SunDepartment of Radiation Oncology, Gustave Roussy, 94800 Villejuif, France.ORCID 0000-0001-9866-6449
Delphine ChenDepartment of Molecular Imaging and Therapy, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Anna M WuDepartment of Immunology and Theranostics, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.ORCID 0000-0001-8487-823X
Tarek AssiInternational Department, Gustave Roussy Cancer Campus, 94805 Villejuif, France.
Samy AmmariDepartment of Medical Imaging, BIOMAPS, UMR1281 INSERM, CEA, CNRS, Gustave Roussy, Université Paris-Saclay, 94800 Villejuif, France.ORCID 0000-0002-1506-0714
Laurent DercleDepartment of Radiology, New York-Presbyterian Hospital, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.ORCID 0000-0002-1322-0710

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The integration of artificial intelligence (AI) and positron emission tomography (PET) imaging has the potential to become a powerful tool in drug discovery. This review aims to provide an overview of the current state of research and highlight the potential for this alliance to advance pharmaceutical innovation by accelerating the development and deployment of novel therapeutics. We previously performed a scoping review of three databases (Embase, MEDLINE, and CENTRAL), identifying 87 studies published between 2018 and 2022 relevant to medical imaging (e.g., CT, PET, MRI), immunotherapy, artificial intelligence, and radiomics. Herein, we reexamine the previously identified studies, performing a subgroup analysis on articles specifically utilizing AI and PET imaging for drug discovery purposes in immunotherapy-treated oncology patients. Of the 87 original studies identified, 15 met our updated search criteria. In these studies, radiomics features were primarily extracted from PET/CT images in combination (

Indexed as

artificial intelligencedrug discoveryimmunotherapyPETPET/CTradiomics

Identifiers

PMID38399425
PMCPMC10892847

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.