Evidence map›Paper›PMID 38399402›Full record

ArticlePharmaceuticals (Basel, Switzerland)2024

Hybrid Molecules of Azithromycin with Chloramphenicol and Metronidazole: Synthesis and Study of Antibacterial Properties.

Inna A Volynkina, Elena N Bychkova, Anastasiia O Karakchieva, Alexander S Tikhomirov, George V Zatonsky, Svetlana E Solovieva, Maksim M Martynov, Natalia E Grammatikova, Andrey G Tereshchenkov, Alena Paleskava and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Inna A VolynkinaDepartment of Chemistry, Lomonosov Moscow State University, Leninskie Gory 1, 119234 Moscow, Russia.
Elena N BychkovaGause Institute of New Antibiotics, B. Pirogovskaya 11, 119021 Moscow, Russia.
Anastasiia O KarakchievaDepartment of Chemistry, Lomonosov Moscow State University, Leninskie Gory 1, 119234 Moscow, Russia.
Alexander S TikhomirovGause Institute of New Antibiotics, B. Pirogovskaya 11, 119021 Moscow, Russia.
George V ZatonskyGause Institute of New Antibiotics, B. Pirogovskaya 11, 119021 Moscow, Russia.
Svetlana E SolovievaGause Institute of New Antibiotics, B. Pirogovskaya 11, 119021 Moscow, Russia.
Maksim M MartynovGause Institute of New Antibiotics, B. Pirogovskaya 11, 119021 Moscow, Russia.
Natalia E GrammatikovaGause Institute of New Antibiotics, B. Pirogovskaya 11, 119021 Moscow, Russia.
Andrey G TereshchenkovDepartment of Chemistry, Lomonosov Moscow State University, Leninskie Gory 1, 119234 Moscow, Russia.ORCID 0000-0002-3293-3951
Alena PaleskavaDepartment of Molecular and Radiation Biophysics, Petersburg Nuclear Physics Institute Named by B.P. Konstantiniv of NRC "Kurchatov Institute", Mkr. Orlova Roshcha 1, 188300 Gatchina, Russia.ORCID 0000-0001-8623-8404
Andrey L KonevegaDepartment of Molecular and Radiation Biophysics, Petersburg Nuclear Physics Institute Named by B.P. Konstantiniv of NRC "Kurchatov Institute", Mkr. Orlova Roshcha 1, 188300 Gatchina, Russia.ORCID 0000-0003-0125-7150
Petr V SergievDepartment of Chemistry, Lomonosov Moscow State University, Leninskie Gory 1, 119234 Moscow, Russia.ORCID 0000-0001-8866-1863
Olga A DontsovaDepartment of Chemistry, Lomonosov Moscow State University, Leninskie Gory 1, 119234 Moscow, Russia.
Ilya A OstermanDepartment of Chemistry, Lomonosov Moscow State University, Leninskie Gory 1, 119234 Moscow, Russia.
Andrey E ShchekotikhinGause Institute of New Antibiotics, B. Pirogovskaya 11, 119021 Moscow, Russia.ORCID 0000-0002-6595-0811
Anna N TevyashovaGause Institute of New Antibiotics, B. Pirogovskaya 11, 119021 Moscow, Russia.ORCID 0000-0003-1091-1011

Funding

Russian Science Foundation 21-64-00006
6 · The paper itself

Abstract

The sustained rise of antimicrobial resistance (AMR) causes a strong need to develop new antibacterial agents. One of the methods for addressing the problem of antibiotic resistance is through the design of hybrid antibiotics. In this work, we proposed a synthetic route for the conjugation of an azithromycin derivative with chloramphenicol and metronidazole hemisuccinates and synthesized two series of new hybrid molecules

Indexed as

70S ribosomeantibacterial activityantibiotic mode of actionazithromycinchloramphenicoldual reporter assayhybrid antibioticsmetronidazole

Identifiers

PMID38399402
PMCPMC10892836

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.