Evidence map›Paper›PMID 38399264›Full record

ArticlePharmaceutics2024

Onchocerciasis Drug Discovery: In Vitro Evaluation of FDA-Approved Drugs against

Suzanne Gokool, Simon Townson, Andrew Freeman, Jadzia Siemienski-Kleyn, Jakub Zubrzycki, Senyo Tagboto, Marc P Hübner, Ivan Scandale

Abstract read
In one paragraph

Article in Pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Suzanne GokoolTropical Parasitic Diseases Unit, Northwick Park Institute for Medical Research, Watford Road, Harrow, London HA1 3UJ, UK.
Simon TownsonTropical Parasitic Diseases Unit, Northwick Park Institute for Medical Research, Watford Road, Harrow, London HA1 3UJ, UK.
Andrew FreemanTropical Parasitic Diseases Unit, Northwick Park Institute for Medical Research, Watford Road, Harrow, London HA1 3UJ, UK.
Jadzia Siemienski-KleynTropical Parasitic Diseases Unit, Northwick Park Institute for Medical Research, Watford Road, Harrow, London HA1 3UJ, UK.
Jakub ZubrzyckiTropical Parasitic Diseases Unit, Northwick Park Institute for Medical Research, Watford Road, Harrow, London HA1 3UJ, UK.
Senyo TagbotoTropical Parasitic Diseases Unit, Northwick Park Institute for Medical Research, Watford Road, Harrow, London HA1 3UJ, UK.
Marc P HübnerInstitute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn, Germany.ORCID 0000-0001-8885-418X
Ivan ScandaleDrugs for Neglected Diseases Initiative, 1202 Geneva, Switzerland.ORCID 0000-0003-4242-9289

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Onchocerciasis treatment and control relies mainly on the use of ivermectin which has high activity against the microfilarial stage of

Indexed as

anthelminticsdrug discoveryFDA-approved drugsmotility and MTT inhibitionO. gutturosaonchocerciasis

Identifiers

PMID38399264
PMCPMC10891533

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.