Evidence map›Paper›PMID 38399250›Full record

ArticlePharmaceutics2024

Antiviral Action against SARS-CoV-2 of a Synthetic Peptide Based on a Novel Defensin Present in the Transcriptome of the Fire Salamander (

Ana Luisa A N Barros, Vladimir C Silva, Atvaldo F Ribeiro-Junior, Miguel G Cardoso, Samuel R Costa, Carolina B Moraes, Cecília G Barbosa, Alex P Coleone, Rafael P Simões, Wanessa F Cabral and 14 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 11 institutions in 4 countries.

Ana Luisa A N BarrosNúcleo de Pesquisa em Morfologia e Imunologia Aplicada, NuPMIA, Faculdade de Medicina, Universidade de Brasília, UnB, Brasília 70910-900, DF, Brazil.ORCID 0000-0001-9077-1877
Vladimir C SilvaLaboratório de Vigilância Genômica e Biologia Molecular-Fundação Oswaldo Cruz Piauí, Teresina 64001-350, PI, Brazil.ORCID 0000-0003-3109-7899
Atvaldo F Ribeiro-JuniorNúcleo de Pesquisa em Morfologia e Imunologia Aplicada, NuPMIA, Faculdade de Medicina, Universidade de Brasília, UnB, Brasília 70910-900, DF, Brazil.
Miguel G CardosoNúcleo de Pesquisa em Morfologia e Imunologia Aplicada, NuPMIA, Faculdade de Medicina, Universidade de Brasília, UnB, Brasília 70910-900, DF, Brazil.
Samuel R CostaInstituto de Química, IQ, Universidade de Brasília, UnB, Brasília 70910-900, DF, Brazil.
Carolina B MoraesDepartment of Pharmaceutical Sciences, Federal University of São Paulo, Diadema 09913-030, SP, Brazil.ORCID 0000-0002-0689-2770
Cecília G BarbosaDepartment of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, São Paulo 05508-000, SP, Brazil.
Alex P ColeonePrograma de Pós-Graduação em Ciência e Tecnologia de Materiais (POSMAT), School of Sciences, São Paulo State University (UNESP), Bauru 17033-360, SP, Brazil.
Rafael P SimõesSchool of Agriculture, Department of Bioprocess and Biotechnology, São Paulo State University (UNESP), Botucatu 18618-689, SP, Brazil.ORCID 0000-0002-3433-8574
Wanessa F CabralNúcleo de Pesquisa em Morfologia e Imunologia Aplicada, NuPMIA, Faculdade de Medicina, Universidade de Brasília, UnB, Brasília 70910-900, DF, Brazil.
Raul M FalcãoBioinformatics Postgraduate Program, Metrópole Digital Institute, Federal University of Rio Grande do Norte, Natal 59078-900, RN, Brazil.
Andreanne G VasconcelosNúcleo de Pesquisa em Morfologia e Imunologia Aplicada, NuPMIA, Faculdade de Medicina, Universidade de Brasília, UnB, Brasília 70910-900, DF, Brazil.ORCID 0000-0002-9651-1598
Jefferson A RochaCampus São Bernardo, Universidade Federal do Maranhão, UFMA, São Bernardo 65550-000, MA, Brazil.ORCID 0000-0001-6619-2293
Daniel D R ArcanjoDepartment of Biophysics and Physiology, Federal University of Piauí, Teresina 64049-550, PI, Brazil.ORCID 0000-0001-7021-2744
Augusto Batagin-NetoPrograma de Pós-Graduação em Ciência e Tecnologia de Materiais (POSMAT), School of Sciences, São Paulo State University (UNESP), Bauru 17033-360, SP, Brazil.ORCID 0000-0003-4609-9002
Tatiana Karla S BorgesNúcleo de Pesquisa em Morfologia e Imunologia Aplicada, NuPMIA, Faculdade de Medicina, Universidade de Brasília, UnB, Brasília 70910-900, DF, Brazil.ORCID 0000-0002-6813-6276
João Gonçalvesimed.ULisboa-Research Institute for Medicines, Faculty of Pharmacy, University of Lisbon, 1649-003 Lisbon, Portugal.
Guilherme D BrandInstituto de Química, IQ, Universidade de Brasília, UnB, Brasília 70910-900, DF, Brazil.
Lucio H G Freitas-JuniorDepartment of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, São Paulo 05508-000, SP, Brazil.
Peter EatonLaboratório Associado para a Química Verde/Rede de Química e Tecnologia (LAQV/REQUIMTE), Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, 4169-007 Porto, Portugal.
Mariela MaraniIPEEC-CONICET, Consejo Nacional de Investigaciones Científicas y Técnicas, Puerto Madryn 9120, Argentina.ORCID 0000-0002-7389-3095
Massuo J KatoInstituto de Química (IQ), Universidade de São Paulo (USP), São Paulo 05508-900, SP, Brazil.ORCID 0000-0002-3315-2129
Alexandra PlácidoLaboratório Associado para a Química Verde/Rede de Química e Tecnologia (LAQV/REQUIMTE), Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, 4169-007 Porto, Portugal.
José Roberto S A LeiteNúcleo de Pesquisa em Morfologia e Imunologia Aplicada, NuPMIA, Faculdade de Medicina, Universidade de Brasília, UnB, Brasília 70910-900, DF, Brazil.ORCID 0000-0002-1096-3236
Universidade de Brasília · BRUniversidade de São Paulo · BRUniversidade Estadual Paulista (Unesp) · BRUniversidade do Porto · PTUniversity of Lisbon · PTCentro Científico Tecnológico Patagónico · ARFundação Oswaldo Cruz · BRUniversidade Federal de São Paulo · BRUniversidade Federal do Maranhão · BRUniversidade Federal do Piauí · BRUniversidade Federal do Rio Grande do Norte · BR

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior 88887.505029/2020-00Coordenação de Aperfeicoamento de Pessoal de Nível Superior 88887.513215/2020-00Fundação para a Ciência e Tecnologia POCI-01-0145-FEDER-031158-PTDC/BII-BIO/31158/2017Fundação para a Ciência e Tecnologia PTDC/BII_BIO/31158/2017
6 · The paper itself

Abstract

The potential emergence of zoonotic diseases has raised significant concerns, particularly in light of the recent pandemic, emphasizing the urgent need for scientific preparedness. The bioprospection and characterization of new molecules are strategically relevant to the research and development of innovative drugs for viral and bacterial treatment and disease management. Amphibian species possess a diverse array of compounds, including antimicrobial peptides. This study identified the first bioactive peptide from

Indexed as

amphibiansantimicrobial peptidesantiviral actionbioinformaticsSARS-CoV-2 infectiontranscriptomics

Identifiers

PMID38399250
PMCPMC10892092
OpenAlexW4391323437

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.