Evidence map›Paper›PMID 38399221›Full record

ReviewPharmaceutics2024

The Fabrication of Polymer-Based Curcumin-Loaded Formulation as a Drug Delivery System: An Updated Review from 2017 to the Present.

Abul Kalam Azad, Joanne Lai, Wan Mohd Azizi Wan Sulaiman, Hassan Almoustafa, Salah Abdalrazak Alshehade, Vinoth Kumarasamy, Vetriselvan Subramaniyan

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Abul Kalam AzadFaculty of Pharmacy, University College of MAIWP International, Batu Caves, Kuala Lumpur 68100, Malaysia.
Joanne LaiFaculty of Pharmacy, MAHSA University, Jenjarom 42610, Selangor, Malaysia.
Wan Mohd Azizi Wan SulaimanFaculty of Pharmacy, University College of MAIWP International, Batu Caves, Kuala Lumpur 68100, Malaysia.
Hassan AlmoustafaFaculty of Medicine, Universiti Malaya, Federal Territory of Kuala Lumpur, Kuala Lumpur 50603, Malaysia.ORCID 0000-0002-2549-1761
Salah Abdalrazak AlshehadeFaculty of Pharmacy & Bio-Medical Sciences, MAHSA University, Petaling Jaya 42610, Selangor, Malaysia.ORCID 0000-0001-8732-1883
Vinoth KumarasamyDepartment of Parasitology and Medical Entomology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Cheras, Kuala Lumpur 56000, Malaysia.ORCID 0000-0002-8895-1796
Vetriselvan SubramaniyanPharmacology Unit, Jeffrey Cheah School of Medicine and Health Sciences, Monash University, Jalan Lagoon Selatan, Bandar Sunway 47500, Selangor, Malaysia.ORCID 0000-0002-9629-9494

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Turmeric contains curcumin, a naturally occurring compound with noted anti-inflammatory and antioxidant properties that may help fight cancer. Curcumin is readily available, nontoxic, and inexpensive. At high doses, it has minimal side effects, suggesting it is safe for human use. However, curcumin has extremely poor bioavailability and biodistribution, which further hamper its clinical applications. It is commonly administered through oral and transdermal routes in different forms, where the particle size is one of the most common barriers that decreases its absorption through biological membranes on the targeted sites and limits its clinical effectiveness. There are many studies ongoing to overcome this problem. All of this motivated us to conduct this review that discusses the fabrication of polymer-based curcumin-loaded formulation as an advanced drug delivery system and addresses different approaches to overcoming the existing barriers and improving its bioavailability and biodistribution to enhance the therapeutic effects against cancer and other diseases.

Indexed as

absorptionbioavailabilitycolon cancercurcuminencapsulationtargeted drug delivery

Identifiers

PMID38399221
PMCPMC10892401

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.