Evidence map›Paper›PMID 38398911›Full record

ReviewMicromachines2024

Hybrid Impedimetric Biosensors for Express Protein Markers Detection.

Nikita Sitkov, Andrey Ryabko, Vyacheslav Moshnikov, Andrey Aleshin, Dmitry Kaplun, Tatiana Zimina

Abstract readReview
In one paragraph

Review in Micromachines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nikita SitkovDepartment of Micro and Nanoelectronics, Saint Petersburg Electrotechnical University "LETI", 197022 Saint Petersburg, Russia.ORCID 0000-0003-4870-8641
Andrey RyabkoLaboratory of Nonequilibrium Processes in Semiconductors, Ioffe Institute, 26 Politekhnicheskaya, 194021 Saint Petersburg, Russia.ORCID 0000-0001-9626-7612
Vyacheslav MoshnikovDepartment of Micro and Nanoelectronics, Saint Petersburg Electrotechnical University "LETI", 197022 Saint Petersburg, Russia.ORCID 0000-0001-6500-5492
Andrey AleshinLaboratory of Nonequilibrium Processes in Semiconductors, Ioffe Institute, 26 Politekhnicheskaya, 194021 Saint Petersburg, Russia.ORCID 0000-0001-5449-4446
Dmitry KaplunArtificial Intelligence Research Institute, China University of Mining and Technology, 1 Daxue Road, Xuzhou 221116, China.ORCID 0000-0003-2765-4509
Tatiana ZiminaDepartment of Micro and Nanoelectronics, Saint Petersburg Electrotechnical University "LETI", 197022 Saint Petersburg, Russia.ORCID 0000-0002-1799-115X

Funding

Russian Science Foundation 23-79-01136
6 · The paper itself

Abstract

Impedimetric biosensors represent a powerful and promising tool for studying and monitoring biological processes associated with proteins and can contribute to the development of new approaches in the diagnosis and treatment of diseases. The basic principles, analytical methods, and applications of hybrid impedimetric biosensors for express protein detection in biological fluids are described. The advantages of this type of biosensors, such as simplicity and speed of operation, sensitivity and selectivity of analysis, cost-effectiveness, and an ability to be integrated into hybrid microfluidic systems, are demonstrated. Current challenges and development prospects in this area are analyzed. They include (a) the selection of materials for electrodes and formation of nanostructures on their surface; (b) the development of efficient methods for biorecognition elements' deposition on the electrodes' surface, providing the specificity and sensitivity of biosensing; (c) the reducing of nonspecific binding and interference, which could affect specificity; (d) adapting biosensors to real samples and conditions of operation; (e) expanding the range of detected proteins; and, finally, (f) the development of biosensor integration into large microanalytical system technologies. This review could be useful for researchers working in the field of impedimetric biosensors for protein detection, as well as for those interested in the application of this type of biosensor in biomedical diagnostics.

Indexed as

antibodiesaptamerselectrochemical impedance spectroscopyexpress detectionimpedimetric biosensorslabel-free detectionmicrofluidicsnanomaterialspeptidesproteins

Identifiers

PMID38398911
PMCPMC10890403

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.