Evidence map›Paper›PMID 38398738›Full record

ReviewLife (Basel, Switzerland)2024

Laccases as Effective Tools in the Removal of Pharmaceutical Products from Aquatic Systems.

Daniela Chmelová, Miroslav Ondrejovič, Stanislav Miertuš

Open access · goldAbstract readReview
In one paragraph

Review in Life (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 34 citations in OpenAlex.

  1. Production ofMolecules (Basel, Switzerland) · 2025
    Article
  2. Article
  3. Immobilization ofJournal of xenobiotics · 2025
    Article
  4. Article
  5. Review
  6. Structure-Function Relationship of the β-Hairpin ofInternational journal of molecular sciences · 2025
    Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Daniela ChmelováDepartment of Biotechnology, Faculty of Natural Sciences, University of Ss. Cyril and Methodius, J. Herdu 2, SK-91701 Trnava, Slovakia.ORCID 0000-0001-9323-5121
Miroslav OndrejovičDepartment of Biotechnology, Faculty of Natural Sciences, University of Ss. Cyril and Methodius, J. Herdu 2, SK-91701 Trnava, Slovakia.ORCID 0000-0003-1870-7840
Stanislav MiertušDepartment of Biotechnology, Faculty of Natural Sciences, University of Ss. Cyril and Methodius, J. Herdu 2, SK-91701 Trnava, Slovakia.ORCID 0000-0001-6766-4571
University of Ss. Cyril and Methodius in Trnava · SKInternational Centre for Applied Research and Sustainable Technology · SK

Funding

Slovak Research and Development Agency APVV-18-0154Slovak Research and Development Agency APVV-21-0108
6 · The paper itself

Abstract

This review aims to provide a comprehensive overview of the application of bacterial and fungal laccases for the removal of pharmaceuticals from the environment. Laccases were evaluated for their efficacy in degrading pharmaceutical substances across various categories, including analgesics, antibiotics, antiepileptics, antirheumatic drugs, cytostatics, hormones, anxiolytics, and sympatholytics. The capability of laccases to degrade or biotransform these drugs was found to be dependent on their structural characteristics. The formation of di-, oligo- and polymers of the parent compound has been observed using the laccase mediator system (LMS), which is advantageous in terms of their removal via commonly used processes in wastewater treatment plants (WWTPs). Notably, certain pharmaceuticals such as tetracycline antibiotics or estrogen hormones exhibited degradation or even mineralization when subjected to laccase treatment. Employing enzyme pretreatment mitigated the toxic effects of degradation products compared to the parent drug. However, when utilizing the LMS, careful mediator selection is essential to prevent potential increases in environment toxicity. Laccases demonstrate efficiency in pharmaceutical removal within WWTPs, operating efficiently under WWTP conditions without necessitating isolation.

Indexed as

biotransformationdegradationenzymelaccasespharmaceuticalsremediationwastewater

Identifiers

PMID38398738
PMCPMC10890127
OpenAlexW4391577051

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.