Evidence map›Paper›PMID 38398728›Full record

ArticleLife (Basel, Switzerland)2024

The Bittersweet Symphony of COVID-19: Associations between

Aurora Santin, Beatrice Spedicati, Alessandro Pecori, Giuseppe Giovanni Nardone, Maria Pina Concas, Gioia Piatti, Anna Menini, Giancarlo Tirelli, Paolo Boscolo-Rizzo, Giorgia Girotto

Open access · goldAbstract read
In one paragraph

Article in Life (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.2field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Nutrients · 2025
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Aurora SantinDepartment of Medicine, Surgery and Health Sciences, University of Trieste, 34149 Trieste, Italy.ORCID 0000-0002-8940-5463
Beatrice SpedicatiDepartment of Medicine, Surgery and Health Sciences, University of Trieste, 34149 Trieste, Italy.ORCID 0000-0002-7432-4708
Alessandro PecoriInstitute for Maternal and Child Health, I.R.C.C.S. "Burlo Garofolo", 34137 Trieste, Italy.ORCID 0000-0001-5926-5757
Giuseppe Giovanni NardoneDepartment of Medicine, Surgery and Health Sciences, University of Trieste, 34149 Trieste, Italy.ORCID 0000-0003-1883-8939
Maria Pina ConcasInstitute for Maternal and Child Health, I.R.C.C.S. "Burlo Garofolo", 34137 Trieste, Italy.ORCID 0000-0003-3598-2537
Gioia PiattiDepartment of Pathophysiology and Transplantation, University of Milan, 20122 Milan, Italy.ORCID 0000-0001-5986-7117
Anna MeniniNeurobiology Group, SISSA, Scuola Internazionale Superiore di Studi Avanzati, 34136 Trieste, Italy.
Giancarlo TirelliDepartment of Medicine, Surgery and Health Sciences, University of Trieste, 34149 Trieste, Italy.
Paolo Boscolo-RizzoDepartment of Medicine, Surgery and Health Sciences, University of Trieste, 34149 Trieste, Italy.
Giorgia GirottoDepartment of Medicine, Surgery and Health Sciences, University of Trieste, 34149 Trieste, Italy.ORCID 0000-0003-4507-6589
University of Trieste · ITIRCCS Materno Infantile Burlo Garofolo · ITScuola Internazionale Superiore di Studi Avanzati · ITUniversity of Milan · IT

Funding

Ministry of Education, Universities and Research D70-RESRICGIROTTO
6 · The paper itself

Abstract

The innate immune system is crucial in fighting SARS-CoV-2 infection, which is responsible for coronavirus disease 2019 (COVID-19). Therefore, deepening our understanding of the underlying immune response mechanisms is fundamental for the development of novel therapeutic strategies. The role of extra-oral bitter (TAS2Rs) and sweet (TAS1Rs) taste receptors in immune response regulation has yet to be fully understood. However, a few studies have investigated the association between taste receptor genes and COVID-19 symptom severity, with controversial results. Therefore, this study aims to deepen the relationship between COVID-19 symptom presence/severity and

Indexed as

COVID-19COVID-19 symptomsimmune responseTAS1R2TAS1R3TAS2R38

Identifiers

PMID38398728
PMCPMC10890446
OpenAlexW4391540148

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.