Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-Mediated Calcium Signaling Is Active in Memory CD4

Anish Chakraborty, Ravindika Dissanayake, Katherine A Wall

Open access · goldAbstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.4field-weighted citation impact, top 42% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Anish ChakrabortyDepartment of Medicinal and Biological Chemistry, University of Toledo, Toledo, OH 43614, USA.

Ravindika DissanayakeDepartment of Medicinal and Biological Chemistry, University of Toledo, Toledo, OH 43614, USA.

Katherine A WallDepartment of Medicinal and Biological Chemistry, University of Toledo, Toledo, OH 43614, USA.ORCID 0000-0002-1150-4736

University of Toledo · US

Funding

Chemobiologic Approach to NAADP SignalingR15GM100444 · NIGMS · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI SLAMA, JAMES T · 2012 to 2012

$351k

NIGMS NIH HHS R15 GM100444NIH HHS R15 GM100444

6 · The paper itself

Abstract

Nicotinic acid adenine dinucleotide phosphate (NAADP), identified as one of the most potent calcium-mobilizing second messengers, has been studied in different eukaryotic cell types, including lymphocytes. Although aspects of NAADP-mediated calcium release in lymphocytes are still under debate, the organelles pertaining to NAADP-mediated calcium release are often characterized as acidic and related to lysosomes. Although NAADP-mediated calcium release in different subsets of T cells, including naïve, effector and natural regulatory T cells, has been studied, it has not been widely studied in memory CD4

Indexed as

CalciumCalcium SignalingAnimalsEndoplasmic ReticulumMiceNADPReceptors, Antigen, T-CellT-Lymphocytes, RegulatoryCalciumNAADPNADPReceptors, Antigen, T-Cellcalcium signalingmemory T cellsNAADPNed-19nicotinic acid adenine dinucleotide phosphateT cell receptor

Identifiers

PMID38398657

DOI10.3390/molecules29040907

PMCPMC10892544

OpenAlexW4392091074

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.