Evidence map›Paper›PMID 38398616›Full record

ArticleMolecules (Basel, Switzerland)2024

Design, Synthesis, Antifungal Evaluation, Structure-Activity Relationship (SAR) Study, and Molecular Docking of Novel Spirotryprostatin A Derivatives.

Yang-Min Ma, Xia Miao, Bin Jia, Zhao-Yang Sun, Si-Yue Ma, Cong Yan

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
6.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Pyrrolidine-Based Antifungal Agents AgainstPharmaceuticals (Basel, Switzerland) · 2026
    Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yang-Min MaKey Laboratory of Chemical Additives for China National Light Industry, College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.ORCID 0000-0002-6980-9532
Xia MiaoKey Laboratory of Chemical Additives for China National Light Industry, College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.
Bin JiaKey Laboratory of Chemical Additives for China National Light Industry, College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.
Zhao-Yang SunKey Laboratory of Chemical Additives for China National Light Industry, College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.
Si-Yue MaKey Laboratory of Chemical Additives for China National Light Industry, College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.
Cong YanKey Laboratory of Chemical Additives for China National Light Industry, College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.
Shaanxi University of Science and Technology · CN

Funding

Key R&D Program of Shaanxi Province 2022GY-203Science and Technology Plan Project of Weiyang District 202114the Agricultural Science and Technology Innovation Project of Shaanxi Province NYKJ-2022-XA-010the fellowship of China Postdoctoral Science Foundation 2022M711994the National Natural Science Foundation of China No. 22178205
6 · The paper itself

Abstract

Phytopathogenic fungi cause plant diseases and economic losses in agriculture. To efficiently control plant pathogen infections, a total of 19 spirotryprostatin A derivatives and 26 spirooxindole derivatives were designed, synthesized, and tested for their antifungal activity against ten plant pathogens. Additionally, the intermediates of spirooxindole derivatives were investigated, including proposing a mechanism for diastereoselectivity and performing amplification experiments. The bioassay results demonstrated that spirotryprostatin A derivatives possess good and broad-spectrum antifungal activities. Compound

Indexed as

Antifungal AgentsBenzopyransFungicides, IndustrialNitrilesOxindolesPiperazinesSpiro CompoundsMolecular Docking SimulationStructure-Activity RelationshipAntifungal AgentsBenzopyransFungicides, IndustrialNitrilesOxindolesPiperazinesSpiro Compoundsspirooxindolespirotryprostatin Achiral fungicidesphytopathogenic fungispirotryprostatin A derivativessuccinate dehydrogenasesynthesis

Identifiers

PMID38398616
PMCPMC11154411
OpenAlexW4391844440

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.