Evidence map›Paper›PMID 38398603›Full record

ArticleMolecules (Basel, Switzerland)2024

The Determination of the Biocompatibility of New Compositional Materials, including Carbamide-Containing Heterocycles of Anti-Adhesion Agents for Abdominal Surgery.

Nurdana Kanasheva, Dmitry A Fedorishin, Maria V Lyapunova, Mikhail V Bukterov, Olga A Kaidash, Abdigali A Bakibaev, Rakhmetulla Yerkassov, Togzhan Mashan, Rimma Nesmeyanova, Vladimir V Ivanov and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Nurdana KanashevaDepartment of Chemistry, L.N. Gumilyov Eurasian National University, Astana 010008, Kazakhstan.ORCID 0009-0006-5272-6526
Dmitry A FedorishinFaculty of Chemistry, National Research Tomsk State University, Tomsk 634028, Russia.ORCID 0000-0001-9492-536X
Maria V LyapunovaFaculty of Chemistry, National Research Tomsk State University, Tomsk 634028, Russia.ORCID 0000-0003-1885-8657
Mikhail V BukterovCentral Research Laboratory, Siberian State Medical University, Tomsk 634050, Russia.
Olga A KaidashCentral Research Laboratory, Siberian State Medical University, Tomsk 634050, Russia.ORCID 0000-0001-8761-7537
Abdigali A BakibaevFaculty of Chemistry, National Research Tomsk State University, Tomsk 634028, Russia.ORCID 0000-0002-3335-3166
Rakhmetulla YerkassovDepartment of Chemistry, L.N. Gumilyov Eurasian National University, Astana 010008, Kazakhstan.
Togzhan MashanDepartment of Chemistry, L.N. Gumilyov Eurasian National University, Astana 010008, Kazakhstan.
Rimma NesmeyanovaDepartment of Chemistry and Chemical Technologies, Faculty of Natural Sciences, Toraighyrov University, Pavlodar 140008, Kazakhstan.
Vladimir V IvanovCentral Research Laboratory, Siberian State Medical University, Tomsk 634050, Russia.
Elena V UdutCentral Research Laboratory, Siberian State Medical University, Tomsk 634050, Russia.
Vera P TuguldurovaFaculty of Chemistry, National Research Tomsk State University, Tomsk 634028, Russia.ORCID 0000-0002-1015-1123
Margarita V SalinaFaculty of Chemistry, National Research Tomsk State University, Tomsk 634028, Russia.
Victor S MalkovFaculty of Chemistry, National Research Tomsk State University, Tomsk 634028, Russia.ORCID 0000-0003-4532-2882
Alexey S KnyazevFaculty of Chemistry, National Research Tomsk State University, Tomsk 634028, Russia.
National Research Tomsk State University · RUSiberian State Medical University · RUL. N. Gumilyov Eurasian National University · KZToraighyrov University · KZ

Funding

CSRD VA 1
6 · The paper itself

Abstract

Due to traumatic injuries, including those from surgical procedures, adhesions occur in over 50% of cases, necessitating exclusive surgical intervention for treatment. However, preventive measures can be implemented during abdominal organ surgeries. These measures involve creating a barrier around internal organs to forestall adhesion formation in the postoperative phase. Yet, the effectiveness of the artificial barrier relies on considerations of its biocompatibility and the avoidance of adverse effects on the body. This study explores the biocompatibility aspects, encompassing hemocompatibility, cytotoxicity, and antibacterial and antioxidant activities, as well as the adhesion of blood serum proteins and macrophages to the surface of new composite film materials. The materials, derived from the sodium salt of carboxymethylcellulose modified by glycoluril and allantoin, were investigated. The research reveals that film materials with a heterocyclic fragment exhibit biocompatibility comparable to commercially used samples in surgery. Notably, film samples developed with glycoluril outperform the effects of commercial samples in certain aspects.

Indexed as

Hyaluronic AcidUreaCarboxymethylcellulose SodiumHumansTissue AdhesionsCarboxymethylcellulose SodiumHyaluronic AcidUreaanti-adhesion agentsbarrier filmsbiocompatibilitycarbamide-containing heterocyclescomposite materialssurgery

Identifiers

PMID38398603
PMCPMC10891942
OpenAlexW4391809671

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.