Evidence map›Paper›PMID 38398590›Full record

ArticleMolecules (Basel, Switzerland)2024

Integrating High-Resolution Mass Spectral Data, Bioassays and Computational Models to Annotate Bioactives in Botanical Extracts: Case Study Analysis of

Armando Alcázar Magaña, Ashish Vaswani, Kevin S Brown, Yuan Jiang, Md Nure Alam, Maya Caruso, Parnian Lak, Paul Cheong, Nora E Gray, Joseph F Quinn and 3 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Armando Alcázar MagañaDepartment of Chemistry, Oregon State University, Corvallis, OR 97331, USA.ORCID 0000-0002-4731-0247
Ashish VaswaniDepartment of Chemistry, Oregon State University, Corvallis, OR 97331, USA.
Kevin S BrownDepartment of Pharmaceutical Sciences, Oregon State University, Corvallis, OR 97331, USA.ORCID 0000-0003-2959-2401
Yuan JiangDepartment of Statistics, Oregon State University, Corvallis, OR 97331, USA.ORCID 0000-0001-6409-9159
Md Nure AlamDepartment of Chemistry, Oregon State University, Corvallis, OR 97331, USA.
Maya CarusoDepartment of Neurology, Oregon Health & Science University, Portland, OR 97239, USA.
Parnian LakDepartment of Chemistry, Oregon State University, Corvallis, OR 97331, USA.
Paul CheongDepartment of Chemistry, Oregon State University, Corvallis, OR 97331, USA.
Nora E GrayBENFRA Botanical Dietary Supplements Research Center, Oregon Health & Science University, Portland, OR 97239, USA.
Joseph F QuinnDepartment of Neurology, Oregon Health & Science University, Portland, OR 97239, USA.ORCID 0000-0001-7305-2256
Amala SoumyanathBENFRA Botanical Dietary Supplements Research Center, Oregon Health & Science University, Portland, OR 97239, USA.ORCID 0000-0003-1569-6453
Jan F StevensBENFRA Botanical Dietary Supplements Research Center, Oregon Health & Science University, Portland, OR 97239, USA.ORCID 0000-0002-6348-9347
Claudia S MaierDepartment of Chemistry, Oregon State University, Corvallis, OR 97331, USA.
Oregon State University · USOregon Health & Science University · US

Funding

Research Education ComponentP30AG066518 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Zachary Beattie · 2020 to 2026
$28.6M
Mechanisms underlying the cognitive effects of Centella asiatica water extract and constituent compounds in the 5xFAD mouse model of Alzheimer's DiseaseU19AT010829 · NCCIH · OREGON HEALTH & SCIENCE UNIVERSITY · PI SOUMYANATH, AMALA · 2020 to 2024
$6.1M
Mechanisms and active compounds in the cognitive effects of Centella asiaticaR01AT008099 · NCCIH · OREGON HEALTH & SCIENCE UNIVERSITY · PI SOUMYANATH, AMALA · 2014 to 2018
$2.2M
HYBRID TRIPLE QUADRUPOLE LINEAR ION TRAP MASS SPECTROMETER: PROSTATE CANCERS10RR022589 · NCRR · OREGON STATE UNIVERSITY · PI STEVENS, JAN FREDERIK · 2006 to 2006
$343k
NCCIH NIH HHS R01 AT008099NCCIH NIH HHS U19 AT010829NIA NIH HHS P30 AG066518NIH HHS R01AT008099NIH HHS S10RR022589NIH HHS U19AT010829
6 · The paper itself

Abstract

Rapid screening of botanical extracts for the discovery of bioactive natural products was performed using a fractionation approach in conjunction with flow-injection high-resolution mass spectrometry for obtaining chemical fingerprints of each fraction, enabling the correlation of the relative abundance of molecular features (representing individual phytochemicals) with the read-outs of bioassays. We applied this strategy for discovering and identifying constituents of

Indexed as

Alzheimer DiseaseCentellaTriterpenesAmyloid beta-PeptidesBiological AssayCognitionComputer SimulationHumansPlant ExtractsQuinic AcidAmyloid beta-Peptidescaffeoylquinic acidPlant ExtractsQuinic AcidTriterpenesbioactivesbioassaysCentella asiaticacomputational methodsElastic NetGNPSneuroprotectionspectral networks

Identifiers

PMID38398590
PMCPMC10892090
OpenAlexW4391822421

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.