Evidence map›Paper›PMID 38398547›Full record

ArticleMolecules (Basel, Switzerland)2024

Characterization of Copper(II) and Zinc(II) Complexes of Peptides Mimicking the CuZnSOD Enzyme.

Enikő Székely, Mariann Molnár, Norbert Lihi, Katalin Várnagy

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Enikő SzékelyDepartment of Inorganic and Analytical Chemistry, University of Debrecen, Egyetem Square 1, H-4032 Debrecen, Hungary.
Mariann MolnárDepartment of Inorganic and Analytical Chemistry, University of Debrecen, Egyetem Square 1, H-4032 Debrecen, Hungary.
Norbert LihiDepartment of Inorganic and Analytical Chemistry, University of Debrecen, Egyetem Square 1, H-4032 Debrecen, Hungary.
Katalin VárnagyDepartment of Inorganic and Analytical Chemistry, University of Debrecen, Egyetem Square 1, H-4032 Debrecen, Hungary.ORCID 0000-0003-0846-4689
University of Debrecen · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial peptides are short cationic peptides that are present on biological surfaces susceptible to infection, and they play an important role in innate immunity. These peptides, like other compounds with antimicrobial activity, often have significant superoxide dismutase (SOD) activity. One direction of our research is the characterization of peptides modeling the CuZnSOD enzyme and the determination of their biological activity, and these results may contribute to the development of novel antimicrobial peptides. In the framework of this research, we have synthesized 10, 15, and 16-membered model peptides containing the amino acid sequence corresponding to the Cu(II) and Zn(II) binding sites of the CuZnSOD enzyme, namely the Zn(II)-binding HVGD sequence (80-83. fragments), the Cu(II)-binding sequence HVH (fragments 46-48), and the histidine (His63), which links the two metal ions as an imidazolate bridge: Ac-FHVHEGPHFN-NH

Indexed as

CopperZincAntimicrobial PeptidesPeptidesSuperoxide DismutaseSuperoxidesAntimicrobial PeptidesCopperPeptidesSuperoxide DismutaseSuperoxidesZincCu(II)-complexCuZnSODmultihistidine peptideSOD activityZn(II)-complex

Identifiers

PMID38398547
PMCPMC10892282
OpenAlexW4391683019

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.