Evidence map›Paper›PMID 38398453›Full record

ArticleJournal of clinical medicine2024

Neurodevelopmental Outcome after Culture-Proven or So-Called Culture-Negative Sepsis in Preterm Infants.

Luca Bedetti, Lucia Corso, Francesca Miselli, Isotta Guidotti, Carlotta Toffoli, Rossella Miglio, Maria Federica Roversi, Elisa Della Casa Muttini, Marisa Pugliese, Natascia Bertoncelli and 5 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Microbial Infections and Antimicrobial Use in Neonates and Infants.Tropical medicine and infectious disease · 2025
    Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Luca BedettiNeonatal Intensive Care Unit, University Hospital of Modena, 41124 Modena, Italy.ORCID 0000-0003-1302-4944
Lucia CorsoPediatric Postgraduate School, University of Modena and Reggio Emilia, 41121 Modena, Italy.ORCID 0000-0003-2102-2674
Francesca MiselliNeonatal Intensive Care Unit, University Hospital of Modena, 41124 Modena, Italy.ORCID 0000-0001-5991-8949
Isotta GuidottiNeonatal Intensive Care Unit, University Hospital of Modena, 41124 Modena, Italy.
Carlotta ToffoliPediatric Postgraduate School, University of Modena and Reggio Emilia, 41121 Modena, Italy.
Rossella MiglioDepartment of Statistical Sciences, University of Bologna, 41121 Bologna, Italy.
Maria Federica RoversiNeonatal Intensive Care Unit, University Hospital of Modena, 41124 Modena, Italy.
Elisa Della Casa MuttiniNeonatal Intensive Care Unit, University Hospital of Modena, 41124 Modena, Italy.
Marisa PuglieseNeonatal Intensive Care Unit, University Hospital of Modena, 41124 Modena, Italy.
Natascia BertoncelliNeonatal Intensive Care Unit, University Hospital of Modena, 41124 Modena, Italy.ORCID 0000-0001-9275-8801
Tommaso ZiniNeonatal Intensive Care Unit, University Hospital of Modena, 41124 Modena, Italy.
Sofia MazzottiPediatric Postgraduate School, University of Modena and Reggio Emilia, 41121 Modena, Italy.ORCID 0009-0006-8005-4261
Licia LugliNeonatal Intensive Care Unit, University Hospital of Modena, 41124 Modena, Italy.ORCID 0000-0002-2149-0083
Laura LucaccioniPediatric Unit, Department of Medical and Surgical Sciences of the Mother, Children and Adults, University of Modena and Reggio Emilia, 41121 Modena, Italy.
Alberto BerardiNeonatal Intensive Care Unit, University Hospital of Modena, 41124 Modena, Italy.ORCID 0000-0002-3534-7499
University of Modena and Reggio Emilia · ITUniversity of Bologna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: Prematurity is a serious condition associated with long-term neurological disability. This study aimed to compare the neurodevelopmental outcomes of preterm neonates with or without sepsis. (2) Methods: This single-center retrospective case-control study included infants with birth weight < 1500 g and/or gestational age ≤ 30 weeks. Short-term outcomes, brain MRI findings, and severe functional disability (SFD) at age 24 months were compared between infants with culture-proven or culture-negative sepsis or without sepsis. A chi-squared test or Mann-Whitney U test was used to compare the clinical and instrumental characteristics and the outcomes between cases and controls. (3) Results: Infants with sepsis (all sepsis n = 76; of which culture-proven n = 33 and culture-negative n = 43) were matched with infants without sepsis (n = 76). Compared with infants without sepsis, both all sepsis and culture-proven sepsis were associated with SFD. In multivariate logistic regression analysis, SFD was associated with intraventricular hemorrhage (OR 4.7, CI 1.7-13.1,

Indexed as

cerebral palsyculture-negative sepsisculture-proven sepsisfunctional disabilityneurodevelopmental follow-upneurodevelopmental outcomenewbornsepsisvery low birth weight

Identifiers

PMID38398453
PMCPMC10889041
OpenAlexW4391948188

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.