Evidence map›Paper›PMID 38398227›Full record

ReviewCancers2024

Role of Cyclins and Cytoskeletal Proteins in Endometriosis: Insights into Pathophysiology.

Marcin Szymański, Klaudia Bonowicz, Paulina Antosik, Dominika Jerka, Mariola Głowacka, Małgorzata Soroka, Kerstin Steinbrink, Konrad Kleszczyński, Maciej Gagat

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
5.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Marcin SzymańskiDepartment of Histology and Embryology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85-092 Bydgoszcz, Poland.
Klaudia BonowiczDepartment of Histology and Embryology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85-092 Bydgoszcz, Poland.ORCID 0000-0002-2098-2799
Paulina AntosikDepartment of Clinical Pathomorphology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85-094 Bydgoszcz, Poland.ORCID 0000-0002-7099-8115
Dominika JerkaDepartment of Histology and Embryology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85-092 Bydgoszcz, Poland.ORCID 0009-0005-3777-598X
Mariola GłowackaFaculty of Medicine, Collegium Medicum, Mazovian Academy in Płock, 08-110 Płock, Poland.ORCID 0000-0002-5734-116X
Małgorzata SorokaFaculty of Medicine, Collegium Medicum, Mazovian Academy in Płock, 08-110 Płock, Poland.
Kerstin SteinbrinkDepartment of Dermatology, University of Münster, Von-Esmarch-Str. 58, 48149 Münster, Germany.ORCID 0000-0002-0500-2158
Konrad KleszczyńskiDepartment of Dermatology, University of Münster, Von-Esmarch-Str. 58, 48149 Münster, Germany.ORCID 0000-0002-1311-263X
Maciej GagatDepartment of Histology and Embryology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85-092 Bydgoszcz, Poland.ORCID 0000-0002-5445-8821
Nicolaus Copernicus University · PLUniversity of Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endometriosis is a gynecological condition where endometrium-like tissue grows outside the uterus, posing challenges in understanding and treatment. This article delves into the deep cellular and molecular processes underlying endometriosis, with a focus on the crucial roles played by cyclins and cytoskeletal proteins in its pathogenesis, particularly in the context of Epithelial-Mesenchymal Transition (EMT). The investigation begins by examining the activities of cyclins, elucidating their diverse biological roles such as cell cycle control, proliferation, evasion of apoptosis, and angiogenesis among ectopic endometrial cells. A comprehensive analysis of cytoskeletal proteins follows, emphasizing their fundamental biological roles and their specific significance to endometriotic cell features. This review sheds light on the interconnected pathways through which cyclins and cytoskeletal proteins converge, contributing to the genesis and progression of endometriosis. Understanding these molecular complexities not only provides insight into the underlying causes of the disease but also holds promise for the development of specific therapeutic approaches, ushering in a new era in the management of this devastating disorder.

Indexed as

cyclinscytoskeletal proteinsEMTendometriosisTGF-β

Identifiers

PMID38398227
PMCPMC10886501
OpenAlexW4391981783

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.