Evidence map›Paper›PMID 38398145›Full record

ReviewCancers2024

The Contemporary Role of Hematopoietic Stem Cell Transplantation in the Management of Chronic Myeloid Leukemia: Is It the Same in All Settings?

Ibrahim Elmakaty, Giuseppe Saglio, Murtadha Al-Khabori, Abdelrahman Elsayed, Basant Elsayed, Mohamed Elmarasi, Ahmed Adel Elsabagh, Awni Alshurafa, Elrazi Ali, Mohamed Yassin

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 4 countries.

Ibrahim ElmakatyCollege of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.ORCID 0000-0002-7227-9042
Giuseppe SaglioDepartment of Clinical and Biological Sciences, University of Turin, 10124 Turin, Italy.
Murtadha Al-KhaboriHematology Department, Sultan Qaboos University, Muscat 123, Oman.ORCID 0000-0002-2937-8838
Abdelrahman ElsayedCollege of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.
Basant ElsayedCollege of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.ORCID 0000-0002-1411-9462
Mohamed ElmarasiCollege of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.
Ahmed Adel ElsabaghCollege of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.ORCID 0000-0002-4927-9888
Awni AlshurafaHematology Section, Medical Oncology, National Center for Cancer Care and Research (NCCCR), Hamad Medical Corporation (HMC), Doha P.O. Box 3050, Qatar.
Elrazi AliInterfaith Medical Center, Brooklyn, NY 11213, USA.
Mohamed YassinCollege of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.ORCID 0000-0002-1144-8076
Qatar University · QANational Center for Cancer Care and Research · QAInterfaith Medical Center · USSultan Qaboos University · OMUniversity of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hematopoietic stem cell transplantation (HSCT) for chronic myeloid leukemia (CML) patients has transitioned from the standard of care to a treatment option limited to those with unsatisfactory tyrosine kinase inhibitor (TKI) responses and advanced disease stages. In recent years, the threshold for undergoing HSCT has increased. Most CML patients now have life expectancies comparable to the general population, and therefore, the goal of therapy is shifting toward achieving treatment-free remission (TFR). While TKI discontinuation trials in CML show potential for achieving TFR, relapse risk is high, affirming allogeneic HSCT as the sole curative treatment. HSCT should be incorporated into treatment algorithms from the time of diagnosis and, in some patients, evaluated as soon as possible. In this review, we will look at some of the recent advances in HSCT, as well as its indication in the era of aiming for TFR in the presence of TKIs in CML.

Indexed as

BCR–ABL1 gene fusionchronic myeloid leukemiahematopoietic stem cell transplantsurvivaltreatment-free remissiontyrosine kinase inhibitors

Identifiers

PMID38398145
PMCPMC10886670
OpenAlexW4391753375

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.