Evidence map›Paper›PMID 38398136›Full record

ReviewCancers2024

Roles of Androgen Receptor Signaling in Urothelial Carcinoma.

Debasish Sundi, Katharine A Collier, Yuanquan Yang, Dayssy Alexandra Diaz, Kamal S Pohar, Eric A Singer, Sanjay Gupta, William E Carson, Steven K Clinton, Zihai Li and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Debasish SundiDepartment of Urology, Division of Urologic Oncology, Pelotonia Institute for Immuno-Oncology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Katharine A CollierDepartment of Internal Medicine, Division of Medical Oncology, Pelotonia Institute for Immuno-Oncology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.ORCID 0000-0003-0485-8031
Yuanquan YangDepartment of Internal Medicine, Division of Medical Oncology, Pelotonia Institute for Immuno-Oncology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Dayssy Alexandra DiazDepartment of Radiation Oncology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.ORCID 0000-0001-6485-5743
Kamal S PoharDepartment of Urology, Division of Urologic Oncology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Eric A SingerDepartment of Urology, Division of Urologic Oncology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Sanjay GuptaDepartment of Urology, Case Western Reserve University School of Medicine, The Urology Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA.ORCID 0000-0002-9492-3249
William E CarsonDepartment of Surgery, Division of Surgical Oncology, Pelotonia Institute for Immuno-Oncology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Steven K ClintonDepartment of Internal Medicine, Division of Medical Oncology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Zihai LiDepartment of Internal Medicine, Division of Medical Oncology, Pelotonia Institute for Immuno-Oncology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Edward M MessingDepartments of Urology, Oncology, and Pathology, University of Rochester Medical Center, Rochester, NY 14642, USA.
The Ohio State University Wexner Medical Center · USUniversity Hospitals of Cleveland · USUniversity of Rochester Medical Center · US

Funding

Paul Calabresis Career Development Award For Clinical Oncology K12CA132783 · NCI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI PEREZ-SOLER, ROMAN, VERMA, AMIT K. · 2009 to 2019
$8.2M
Characterizing the immune infiltrate in muscle-invasive urothelial carcinomaK08CA277016 · NCI · OHIO STATE UNIVERSITY · PI Katharine A. Collier · 2023 to 2026
$1.1M
NCI NIH HHS K08 CA277016NCI NIH HHS K12 CA132783
6 · The paper itself

Abstract

Preclinical and clinical data suggest that androgen receptor signaling strongly contributes to bladder cancer development. The roles of the androgen receptor in bladder carcinogenesis have obvious implications for understanding the strong male sex bias in this disease and for potential therapeutic strategies as well. In this review, we summarize what is known about androgen receptor signaling in urothelial carcinoma as well as in tumor-infiltrating immune cells, reviewing preclinical and clinical data. We also highlight clinical trial efforts in this area.

Indexed as

androgen receptoranti-tumor immunitybladder cancer

Identifiers

PMID38398136
PMCPMC10886823
OpenAlexW4391753976

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.