Evidence map›Paper›PMID 38398089›Full record

ReviewCancers2024

Systematic Review of Preoperative Prognostic Biomarkers in Perihilar Cholangiocarcinoma.

Rishaan Pawaskar, Kevin Zhang Huang, Helen Pham, Adnan Nagrial, Mark Wong, Siobhan O'Neill, Henry Pleass, Lawrence Yuen, Vincent W T Lam, Arthur Richardson and 2 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Rishaan PawaskarDepartment of Upper GI Surgery, Westmead Hospital, Sydney, NSW 2145, Australia.
Kevin Zhang HuangWestmead Hospital, Sydney, NSW 2145, Australia.
Helen PhamDepartment of Upper GI Surgery, Westmead Hospital, Sydney, NSW 2145, Australia.
Adnan NagrialWestmead Clinical School, Faculty of Medicine and Health Sciences, The University of Sydney, Sydney, NSW 2006, Australia.
Mark WongWestmead Clinical School, Faculty of Medicine and Health Sciences, The University of Sydney, Sydney, NSW 2006, Australia.
Siobhan O'NeillCrown Princess Mary Cancer Centre, Westmead Hospital, Sydney, NSW 2145, Australia.
Henry PleassDepartment of Upper GI Surgery, Westmead Hospital, Sydney, NSW 2145, Australia.
Lawrence YuenDepartment of Upper GI Surgery, Westmead Hospital, Sydney, NSW 2145, Australia.
Vincent W T LamDepartment of Upper GI Surgery, Westmead Hospital, Sydney, NSW 2145, Australia.
Arthur RichardsonDepartment of Upper GI Surgery, Westmead Hospital, Sydney, NSW 2145, Australia.
Tony PangDepartment of Upper GI Surgery, Westmead Hospital, Sydney, NSW 2145, Australia.
Christopher B NahmDepartment of Upper GI Surgery, Westmead Hospital, Sydney, NSW 2145, Australia.ORCID 0000-0003-0888-4499
The University of Sydney · AUWestmead Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Perihilar cholangiocarcinoma (pCCA) is an uncommon malignancy with generally poor prognosis. Surgery is the primary curative treatment; however, the perioperative mortality and morbidity rates are high, with a low 5-year survival rate. Use of preoperative prognostic biomarkers to predict survival outcomes after surgery for pCCA are not well-established currently. This systematic review aimed to identify and summarise preoperative biomarkers associated with survival in pCCA, thereby potentially improving treatment decision-making. The Embase, Medline, and Cochrane databases were searched, and a systematic review was performed using the PRISMA guidelines. English-language studies examining the association between serum and/or tissue-derived biomarkers in pCCA and overall and/or disease-free survival were included. Our systematic review identified 64 biomarkers across 48 relevant studies. Raised serum CA19-9, bilirubin, CEA, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and tumour MMP9, and low serum albumin were most associated with poorer survival; however, the cutoff values used widely varied. Several promising molecular markers with prognostic significance were also identified, including tumour HMGA2, MUC5AC/6, IDH1, PIWIL2, and DNA index. In conclusion, several biomarkers have been identified in serum and tumour specimens that prognosticate overall and disease-free survival after pCCA resection. These, however, require external validation in large cohort studies and/or in preoperatively obtained specimens, especially tissue biopsy, to recommend their use.

Indexed as

biomarkersdisease-free survivaloverall survivalperihilar cholangiocarcinomaprognosis

Identifiers

PMID38398089
PMCPMC10886549
OpenAlexW4391613054

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.