ArticleBiomedicines2024
Quantitative Evaluation by Digital Pathology of Immunohistochemical Expression of CK7, CK19, and EpCAM in Advanced Stages of NASH.
Daniela Cabibi, Antonino Giulio Giannone, Alberto Quattrocchi, Vincenza Calvaruso, Rossana Porcasi, Domenico Di Grusa, Anna Maria Pavone, Albert Comelli, Salvatore Petta
Open access · goldAbstract read
In one paragraphArticle in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors at 2 institutions in 1 country.
Daniela CabibiUnit of Anatomic Pathology, Department of Health Promotion Mother and Child Care Internal Medicine and Medical Specialties (PROMISE), University Hospital AOU Policlinico "P. Giaccone", University of Palermo, Via del Vespro 129, 90127 Palermo, Italy.ORCID 0000-0001-6571-6577 Antonino Giulio GiannoneUnit of Anatomic Pathology, Department of Health Promotion Mother and Child Care Internal Medicine and Medical Specialties (PROMISE), University Hospital AOU Policlinico "P. Giaccone", University of Palermo, Via del Vespro 129, 90127 Palermo, Italy.ORCID 0000-0002-1219-627X Alberto QuattrocchiUnit of Anatomic Pathology, Department of Health Promotion Mother and Child Care Internal Medicine and Medical Specialties (PROMISE), University Hospital AOU Policlinico "P. Giaccone", University of Palermo, Via del Vespro 129, 90127 Palermo, Italy.ORCID 0000-0001-7034-4915 Vincenza CalvarusoSection of Gastroenterology and Hepatology, Department of Health Promotion Mother and Child Care Internal Medicine and Medical Specialties (PROMISE), University Hospital AOU Policlinico "P. Giaccone", University of Palermo, Via del Vespro 129, 90127 Palermo, Italy.ORCID 0000-0002-0287-1059 Rossana PorcasiUnit of Anatomic Pathology, Department of Health Promotion Mother and Child Care Internal Medicine and Medical Specialties (PROMISE), University Hospital AOU Policlinico "P. Giaccone", University of Palermo, Via del Vespro 129, 90127 Palermo, Italy.
Domenico Di GrusaUnit of Anatomic Pathology, Department of Health Promotion Mother and Child Care Internal Medicine and Medical Specialties (PROMISE), University Hospital AOU Policlinico "P. Giaccone", University of Palermo, Via del Vespro 129, 90127 Palermo, Italy.
Anna Maria PavoneRi.MED Foundation, Via Bandiera 11, 90133 Palermo, Italy.
Salvatore PettaSection of Gastroenterology and Hepatology, Department of Health Promotion Mother and Child Care Internal Medicine and Medical Specialties (PROMISE), University Hospital AOU Policlinico "P. Giaccone", University of Palermo, Via del Vespro 129, 90127 Palermo, Italy.
Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo · ITRi.MED · IT
Funding
European Union - NextGenerationEU through the Italian Ministry of University and Research PNRR -M4C2-I1.3 Project PE_00000019 "HEAL ITALIA"
6 · The paper itselfAbstract
(1) Background: Nonalcoholic Steatohepatitis/Nonalcoholic Fatty Liver Disease (NASH/NAFLD) is the most recurrent chronic liver disease. NASH could present with a cholestatic (C) or hepatic (H) pattern of damage. Recently, we observed that increased Epithelial Cell Adhesion Molecule (EpCAM) expression was the main immunohistochemical feature to distinguish C from H pattern in NASH. (2) Methods: In the present study, we used digital pathology to compare the quantitative results of digital image analysis by QuPath software (Q-results), with the semi-quantitative results of observer assessment (S-results) for cytokeratin 7 and 19, (CK7, CK19) as well as EpCAM expression. Patients were classified into H or C group on the basis of the ratio between alanine transaminase (ALT) and alkaline phosphatase (ALP) values, using the "R-ratio formula". (3) Results: Q- and S-results showed a significant correlation for all markers (
Indexed as
biliary metaplasiadigital pathologyductular proliferationimmunohistochemistryliver biopsyNASHQuPath
Identifiers
PMID38398042
PMCPMC10887071
OpenAlexW4391883886
What OpenQuestion holds
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LicenceCC BY
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