Evidence map›Paper›PMID 38398003›Full record

ArticleBiomedicines2024

The Glymphatic Response to the Development of Type 2 Diabetes.

Edward D Boyd, Li Zhang, Guangliang Ding, Lian Li, Mei Lu, Qingjiang Li, Rui Huang, Jasleen Kaur, Jiani Hu, Michael Chopp and 2 more

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Diabetes-Associated Cognitive Impairment: Pathophysiology and Emerging Therapies.Annals of clinical and translational neurology · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Loss of glymphatic homeostasis in heart failure.Brain : a journal of neurology · 2025
    Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Edward D BoydDepartment of Neurology, Henry Ford Health System, E&R B126, 2799 West Grand Boulevard, Detroit, MI 48202, USA.
Li ZhangDepartment of Neurology, Henry Ford Health System, E&R B126, 2799 West Grand Boulevard, Detroit, MI 48202, USA.
Guangliang DingDepartment of Neurology, Henry Ford Health System, E&R B126, 2799 West Grand Boulevard, Detroit, MI 48202, USA.
Lian LiDepartment of Neurology, Henry Ford Health System, E&R B126, 2799 West Grand Boulevard, Detroit, MI 48202, USA.
Mei LuDepartment of Public Health Sciences, Henry Ford Health System, Detroit, MI 48202, USA.
Qingjiang LiDepartment of Neurology, Henry Ford Health System, E&R B126, 2799 West Grand Boulevard, Detroit, MI 48202, USA.
Rui HuangDepartment of Neurology, Henry Ford Health System, E&R B126, 2799 West Grand Boulevard, Detroit, MI 48202, USA.
Jasleen KaurDepartment of Neurology, Henry Ford Health System, E&R B126, 2799 West Grand Boulevard, Detroit, MI 48202, USA.ORCID 0000-0002-0835-3615
Jiani HuDepartment of Radiology, Wayne State University, Detroit, MI 48202, USA.
Michael ChoppDepartment of Neurology, Henry Ford Health System, E&R B126, 2799 West Grand Boulevard, Detroit, MI 48202, USA.
Zhenggang ZhangDepartment of Neurology, Henry Ford Health System, E&R B126, 2799 West Grand Boulevard, Detroit, MI 48202, USA.
Quan JiangDepartment of Neurology, Henry Ford Health System, E&R B126, 2799 West Grand Boulevard, Detroit, MI 48202, USA.
Henry Ford Health System · USWayne State University · US

Funding

Interaction between glymphatic and vascular systems for waste clearance in brain - Administrative SupplementR01NS108463 · NINDS · HENRY FORD HEALTH SYSTEM · PI HU, JIANI, JIANG, QUAN · 2018 to 2022
$3.1M
Glymphatic and cognitive impairment of aging and diabetesRF1AG057494 · NIA · HENRY FORD HEALTH SYSTEM · PI JIANG, QUAN, ZHANG, LI · 2017 to 2017
$2.9M
Cerebral endothelial cells derived exosomes as a therapy for cognitive impairment in aged diabetic ratsR01AG068072 · NIA · HENRY FORD HEALTH SYSTEM · PI ZHANG, LI · 2021 to 2025
$1.8M
Imaging cerebral waste clearance responses during exosome treatment of diabetesR01DK136843 · NIDDK · HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES · PI QUAN JIANG, LI ZHANG · 2024 to 2026
$1.8M
Modeling glymphatic system and application for agingR21AG070173 · NIA · HENRY FORD HEALTH SYSTEM · PI BOYD, EDWARD DAVOODI · 2022 to 2023
$418k
Impairment of the glymphatic system in the aged diabetic brainR21AG052735 · NIA · HENRY FORD HEALTH SYSTEM · PI JIANG, QUAN, ZHANG, LI · 2016 to 2017
$412k
NIA NIH HHS R01 AG068072NIA NIH HHS R21 AG052735NIA NIH HHS R21 AG070173NIA NIH HHS RF1 AG057494NIDDK NIH HHS R01 DK136843NIH HHS R01AG068072NIH HHS R01DK136843NIH HHS R01-NS108463NIH HHS R21-AG052735NIH HHS R21-AG070173NIH HHS RF1-AG057494NINDS NIH HHS R01 NS108463
6 · The paper itself

Abstract

The glymphatic system has recently been shown to be important in neurological diseases, including diabetes. However, little is known about how the progressive onset of diabetes affects the glymphatic system. The aim of this study is to investigate the glymphatic system response to the progressive onset of diabetes in a rat model of type 2 diabetic mellitus. Male Wistar rats (

Indexed as

cerebrospinal fluid interstitial fluid exchangecognitive deficitsglymphatic systemimmuno-histopathologymagnetic resonance imaging

Identifiers

PMID38398003
PMCPMC10886551
OpenAlexW4391679735

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.