Evidence map›Paper›PMID 38397937›Full record

ArticleBiomedicines2024

Biomarkers of Innate Immunity and Immunological Susceptibility to Viral Infection in Patients with Alcoholic Cirrhosis.

Isabel Legaz, Elena Navarro-Noguera, Aurelia Collados-Ros, Jose Miguel Bolarín, Manuel Muro

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Isabel LegazDepartment of Legal and Forensic Medicine, Biomedical Research Institute of Murcia (IMIB), Regional Campus of International Excellence "Campus Mare Nostrum", Faculty of Medicine, University of Murcia (UMU), 30100 Murcia, Spain.ORCID 0000-0002-1140-4313
Elena Navarro-NogueraDigestive Medicine Service, Hospital Clinico Universitario Virgen de la Arrixaca (HCUVA), 30120 Murcia, Spain.
Aurelia Collados-RosDepartment of Legal and Forensic Medicine, Biomedical Research Institute of Murcia (IMIB), Regional Campus of International Excellence "Campus Mare Nostrum", Faculty of Medicine, University of Murcia (UMU), 30100 Murcia, Spain.
Jose Miguel BolarínDepartment of Legal and Forensic Medicine, Biomedical Research Institute of Murcia (IMIB), Regional Campus of International Excellence "Campus Mare Nostrum", Faculty of Medicine, University of Murcia (UMU), 30100 Murcia, Spain.ORCID 0000-0003-2400-9213
Manuel MuroImmunology Service, University Clinical Hospital "Virgen de la Arrixaca"-IMIB, 30120 Murcia, Spain.ORCID 0000-0001-9987-0994
Universidad de Murcia · ESHospital Universitario Virgen de la Arrixaca · ES

Funding

European Union through the European Fund of Regional Development (FEDER) "A manner to build Europe"Fundacion Mutua Madrileña AP183152023Instituto de Salud Carlos III P19/01194
6 · The paper itself

Abstract

backgroundThe harmful effect of alcohol on the immune system may be due to both a direct action of the alcohol or its metabolites on immune cells as an indirect action modifying the different mechanisms of intercellular interaction. The interplay between stimulatory (aKIR) and inhibitory (iKIR) natural killer (NK) cell receptors and their corresponding human leukocyte antigen (HLA) ligands influences the outcome of virus infection. The aim was to analyze the influence of the KIR/HLA pair genetic profile in male alcoholic cirrhosis (AC) patients with and without viral infections to find susceptibility biomarkers that can help establish the risks and prevent viral infections.

methodsA total of 281 male AC patients were analyzed. The sociodemographic characteristics, viral hepatitis C (HCV), hepatitis B (HBV), and cytomegalovirus (CMV) infections were analyzed. Genomic DNA was extracted, and genetic the

resultsA statistically significant increase in the combination of

conclusionsThe genetic

Indexed as

alcoholcirrhosishuman toxicologyKIR/HLA genesNK cellsvirus

Identifiers

PMID38397937
PMCPMC10887413
OpenAlexW4391431780

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.