Evidence map›Paper›PMID 38397900›Full record

ArticleBiomedicines2024

Gut Fungal Microbiota Alterations in Pulmonary Arterial Hypertensive Rats.

Yihang Chen, Liukun Meng, Wen Yuan, Zehan Gao, Xun Zhang, Boqia Xie, Jiawei Song, Jifeng Li, Jiuchang Zhong, Xiaoyan Liu

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Yihang ChenDepartment of Cardiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
Liukun MengState Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100032, China.
Wen YuanMedical Research Center, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
Zehan GaoDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
Xun ZhangInstitute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.ORCID 0000-0002-7210-7451
Boqia XieDepartment of Cardiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
Jiawei SongDepartment of Cardiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
Jifeng LiDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.ORCID 0000-0002-0418-6151
Jiuchang ZhongDepartment of Cardiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.ORCID 0000-0002-2315-3515
Xiaoyan LiuDepartment of Cardiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.ORCID 0000-0002-1732-5923
Capital Medical University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNChinese Academy of Sciences · CN

Funding

Beijing Hospitals Authority Youth Program QML20200305Clinical Research Incubation Program of Beijing Chaoyang Hospital Affiliated to Capital Medical University CYFH202209National Natural Science Foundation of China 82170302,92168117, 82370432Natural Science Foundation of Beijing 7222068the 2024 Reform and Development Program of Beijing Institute of Respiratory Medicine Ggyfz202308
6 · The paper itself

Abstract

The gut microbiome's imbalance has been implicated in the pathogenesis of pulmonary arterial hypertension (PAH), yet the contribution of the gut mycobiome remains largely unclear. This study delineates the gut mycobiome profile in PAH and examines its interplay with the bacterial microbiome alterations. Fecal samples from monocrotaline-induced PAH rats and matched controls were subjected to internal transcribed spacer 1 (ITS1) sequencing for fungal community assessment and 16S ribosomal RNA (rRNA) gene sequencing for bacterial community characterization. Comparative analysis revealed no significant disparities in the overall mycobiome diversity between the PAH and control groups. However, taxonomic profiling identified differential mycobiome compositions, with the PAH group exhibiting a significant enrichment of genera such as

Indexed as

fungiinternal transcribed spacer 1microbiomemycobiomepulmonary arterial hypertension

Identifiers

PMID38397900
PMCPMC10886911
OpenAlexW4391312017

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.