ArticleAntioxidants (Basel, Switzerland)2024
Maternal Malic Acid May Ameliorate Oxidative Stress and Inflammation in Sows through Modulating Gut Microbiota and Host Metabolic Profiles during Late Pregnancy.
Article in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Article
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- Dietary Houttuynia cordata Thunb attenuates redox imbalance and inflammation possibly induced by heat stress in dairy cows associated with altered fecal microbiota and metabolomics profile.Tropical animal health and production · 2025Article
- Dietary Supplementation with Protocatechuic Acid and a ComplexAnimals : an open access journal from MDPI · 2025Article
- Article
- Exploratory Evaluation of Circulating Microbiota-Derived Corisin Levels in Women with Adverse Pregnancy Outcomes.Antioxidants (Basel, Switzerland) · 2025Article
- Maternal supplementation of Lonicera flos and Scutellaria Baicalensis mixed extracts improve reproduction performance and metabolic health through modulating gut microbiota during pregnancy.BMC veterinary research · 2025Article
- Microbiome-Maternal Tract Interactions in Women with Recurrent Implantation Failure.Microorganisms · 2025Review
- Fecal metabolomic analysis of the role of gut microbiota and short-chain fatty acids in the therapeutic mechanism of Timosaponin AIII in Sjögren's syndrome.Clinical rheumatology · 2025Article
- Chromium yeast promotes milk protein synthesis by regulating ruminal microbiota and amino acid metabolites in heat-stressed dairy cows.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- The influence of resveratrol and β-Hydroxy-β-methyl butyric acid supplementation alone or in combination on the development and health of the duodenum in Tibetan sheep.Frontiers in microbiology · 2025Article
- Dietary supplement ofFrontiers in microbiology · 2025Article
- Hydroxysafflor yellow A alleviates oxidative stress and inflammatory damage in the livers of mice with nonalcoholic fatty liver disease and modulates gut microbiota.Frontiers in pharmacology · 2025Article
- Prognostic value of gut microbiota and low-density lipoprotein cholesterol subfractions in patients with ST-segment elevation myocardial infarction.Frontiers in immunology · 2025Article
- Microbiome and metabolomics analyses of the effect of heat-sensitive moxibustion on allergic rhinitis in rats.Frontiers in immunology · 2025Article
- Essential amino acids preserve intestinal barrier integrityFrontiers in pharmacology · 2025Article
- Metabolomics reveals the potential metabolic mechanism of infliximab against DSS-induced acute and chronic ulcerative colitis.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Effect of host breeds on gut microbiome and fecal metabolome in commercial pigs.BMC veterinary research · 2024Article
- The maternal lifestyle in pregnancy: Implications for foetal skeletal muscle development.Journal of cachexia, sarcopenia and muscle · 2024Review
- Ningxiang Pig-Derived Microbiota Affects the Growth Performance, Gut Microbiota, and Serum Metabolome of Nursery Pigs.Animals : an open access journal from MDPI · 2024Article
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
Sows suffer oxidative stress and inflammation induced by metabolic burden during late pregnancy, which negatively regulates reproductive and lactating performances. We previously found that L-malic acid (MA) alleviated oxidative stress and inflammation and improved reproductive performances in sows. However, the mechanism underlying the MA's positive effects remains unexplored. Here, twenty Large White × Landrace sows with similar parity were randomly divided into two groups and fed with a basal diet or a diet supplemented with 2% L-malic acid complex from day 85 of gestation to delivery. The gut microbiome, fecal short-chain fatty acids, and untargeted serum metabolome were determined. Results showed that Firmicutes, Bacteroidota, and Spirochaetota were the top abundant phyla identified in late pregnancy for sows. Maternal MA supplementation modulated the composition but not the richness and diversity of gut microbiota during late pregnancy. Correlation analysis between gut microbiota and antioxidant capacity (or inflammation indicators) revealed that
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