Evidence map›Paper›PMID 38397822›Full record

ArticleAntioxidants (Basel, Switzerland)2024

Carbon Nanodots Inhibit Tumor Necrosis Factor-α-Induced Endothelial Inflammation through Scavenging Hydrogen Peroxide and Upregulating Antioxidant Gene Expression in EA.hy926 Endothelial Cells.

Jessica Chavez, Ajmal Khan, Kenna R Watson, Safeera Khan, Yaru Si, Alexandra Y Deng, Grant Koher, Mmesoma S Anike, Xianwen Yi, Zhenquan Jia

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Nanomaterials-Based Immunotherapy for Atherosclerosis.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  2. Ectoine attenuates HFrontiers in aging · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Jessica ChavezDepartment of Biology, University of North Carolina at Greensboro, Greensboro, NC 27412, USA.
Ajmal KhanDepartment of Biology, University of North Carolina at Greensboro, Greensboro, NC 27412, USA.ORCID 0000-0001-9703-2428
Kenna R WatsonDepartment of Biology, University of North Carolina at Greensboro, Greensboro, NC 27412, USA.
Safeera KhanDepartment of Biology, University of North Carolina at Greensboro, Greensboro, NC 27412, USA.
Yaru SiDepartment of Biology, University of North Carolina at Greensboro, Greensboro, NC 27412, USA.
Alexandra Y DengChapel Hill High School, Chapel Hill, NC 27516, USA.
Grant KoherDepartment of Biology, University of North Carolina at Greensboro, Greensboro, NC 27412, USA.
Mmesoma S AnikeDepartment of Biology, University of North Carolina at Greensboro, Greensboro, NC 27412, USA.
Xianwen YiDepartment of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Zhenquan JiaDepartment of Biology, University of North Carolina at Greensboro, Greensboro, NC 27412, USA.ORCID 0000-0002-5187-1549
University of North Carolina at Greensboro · USChapel Hill Carrboro City Schools · USUniversity of North Carolina at Chapel Hill · US

Funding

Novel Carbon Nanodots against Vascular InflammationR15HL129212 · NHLBI · UNIVERSITY OF NORTH CAROLINA GREENSBORO · PI JIA, ZHENQUAN · 2016 to 2016
$455k
Novel carbon nanodots for modulation of OxLDL mediated inflammation and inhibition of atherosclerosisR15HL150664 · NHLBI · UNIVERSITY OF NORTH CAROLINA GREENSBORO · PI JIA, ZHENQUAN · 2020 to 2020
$447k
National Institute of Health 1R15HL129212-01A1 and 1R15HL150664-01A1NHLBI NIH HHS R15 HL129212NHLBI NIH HHS R15 HL150664
6 · The paper itself

Abstract

Carbon nanodots (CNDs) are a new type of nanomaterial with a size of less than 10 nanometers and excellent biocompatibility, widely used in fields such as biological imaging, transmission, diagnosis, and drug delivery. However, its potential and mechanism to mediate endothelial inflammation have yet to be explored. Here, we report that the uptake of CNDs by EA.hy926 endothelial cells is both time and dose dependent. The concentration of CNDs used in this experiment was found to not affect cell viability. TNF-α is a known biomarker of vascular inflammation. Cells treated with CNDs for 24 h significantly inhibited TNF-α (0.5 ng/mL)-induced expression of intracellular adhesion molecule 1 (

Indexed as

carbon nanodotsROStumor necrosis factor-alphavascular inflammation

Identifiers

PMID38397822
PMCPMC10885878
OpenAlexW4391753443

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.