ReviewAntioxidants (Basel, Switzerland)2024
Ozone Exposure Controls Oxidative Stress and the Inflammatory Process of Hepatocytes in Murine Models.
Review in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Depression Mediates the Association Between Ambient Air Pollution and Gastrointestinal/Liver Diseases: A Prospective Cohort Study.CNS neuroscience & therapeutics · 2026Article
- Combined effects of nitrogen dioxide and ozone air pollution on maternal liver function during pregnancy: a birth cohort study in China.Environmental health and preventive medicine · 2026Article
- The impact of air pollution on non-alcoholic fatty liver disease: A global ecological analysis of incidence and mortality trends by human development index (1990-2019).Journal of diabetes and metabolic disorders · 2025Article
- Oxygen-Ozone Therapy in Tendinopathy Management: A Comprehensive Review.Journal of personalized medicine · 2025Review
- Article
- The effects of ozone exposure on apoptotic mechanisms in Colo-320 and Colo-741 cell lines: implications for cancer therapy.Journal of molecular histology · 2025Article
- Ambient Air Pollution and Congenital Heart Disease: Updated Evidence and Future Challenges.Antioxidants (Basel, Switzerland) · 2025Review
- Effects of 10- and 30-minute Hepatic Ischemia on Total Protein, Albumin, Globulin Fractions, and LDH of Male Albino Rates; An Experimental Study.Archives of academic emergency medicine · 2025Article
- Effects of Ozone Therapy on Adverse Events and Inflammatory Markers in Patients With Hepatocellular Carcinoma Undergoing Interventional Therapy.Gastroenterology research and practice · 2025Article
- Puerarin: a hepatoprotective drug from bench to bedside.Chinese medicine · 2024Review
- Evaluation of the Efficacy of Ozone Therapy on Liver Tissue in the Treatment of Sepsis in Rats with Cecal Perforation.Medicina (Kaunas, Lithuania) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
(1) Background: Ozone exposure is a promising tool for treating liver damage since it is known to control the release of free radicals and increase the expression of antioxidant enzymes. The objective is to investigate the main intracellular pathways activated after exposure to ozone, considering the dosage of antioxidant enzymes and markers of oxidative stress. (2) Methods: This systematic review was performed based on the PRISMA guidelines and using a structured search in MEDLINE (PubMed), Scopus, and Web of Science. Bias analysis and methodological quality assessments were examined using the SYRCLE Risk of Bias tool. (3) Results: Nineteen studies were selected. The results showed that the exposure to ozone has a protective effect on liver tissue, promoting a decrease in inflammatory markers and a reduction in oxidative stress in liver tissue. In addition, ozone exposure also promoted an increase in antioxidant enzymes. The morphological consequences of controlling these intracellular pathways were reducing the tissue inflammatory process and reducing areas of degeneration and necrosis. (4) Conclusions: Ozone exposure has a beneficial effect on models of liver injury through the decrease in oxidative stress in tissue and inflammatory markers. In addition, it regulates the Nrf2/ARE antioxidant pathway and blocks the NF-κB inflammatory pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.