Evidence map›Paper›PMID 38397781›Full record

ArticleAntioxidants (Basel, Switzerland)2024

Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Ameliorate Aging-Induced BTB Impairment in Porcine Testes by Activating Autophagy and Inhibiting ROS/NLRP3 Inflammasomes via the AMPK/mTOR Signaling Pathway.

Yi Zhou, Jiale Yan, Limin Qiao, Jiaqin Zeng, Fuyu Cao, Xihui Sheng, Xiaolong Qi, Cheng Long, Bingying Liu, Xiangguo Wang and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
6.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Yi ZhouAnimal Science and Technology College, Beijing University of Agriculture, Beijing 102206, China.
Jiale YanAnimal Science and Technology College, Beijing University of Agriculture, Beijing 102206, China.
Limin QiaoDepartment of Animal Husbandry and Veterinary, Beijing Vocational College of Agriculture, Beijing 102445, China.
Jiaqin ZengAnimal Science and Technology College, Beijing University of Agriculture, Beijing 102206, China.
Fuyu CaoAnimal Science and Technology College, Beijing University of Agriculture, Beijing 102206, China.
Xihui ShengAnimal Science and Technology College, Beijing University of Agriculture, Beijing 102206, China.
Xiaolong QiAnimal Science and Technology College, Beijing University of Agriculture, Beijing 102206, China.
Cheng LongAnimal Science and Technology College, Beijing University of Agriculture, Beijing 102206, China.
Bingying LiuAnimal Science and Technology College, Beijing University of Agriculture, Beijing 102206, China.
Xiangguo WangAnimal Science and Technology College, Beijing University of Agriculture, Beijing 102206, China.ORCID 0000-0002-5001-7930
Hua YaoAnimal Science and Technology College, Beijing University of Agriculture, Beijing 102206, China.
Longfei XiaoAnimal Science and Technology College, Beijing University of Agriculture, Beijing 102206, China.ORCID 0000-0001-5790-6645
Beijing University of Agriculture · CNBeijing Health Vocational College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As a pivotal player in spermatogenesis, the blood-testis barrier (BTB) made from junction apparatus coexisting in Sertoli cells (SCs) is impaired with an increase in age and ultimately induces spermatogenic dysfunction or even infertility. It has been corroborated that bone marrow mesenchymal stem cell (BMSC) transplantation can efficiently repair and regenerate the testicular function. As vital mediators of cell-to-cell communication, MSC-derived exosomes (Exos) can directly serve as therapeutic agents for tissue repair and regeneration. However, the therapeutic value of BMSC-Exos in aging-induced BTB damage remains to be confirmed. In this study, we explored that the old porcine testes had defective autophagy, which aggravated BTB disruption in SCs. BMSC-Exos could decrease ROS production and NLRP3 inflammasome activation but enhanced autophagy and tight junction (TJ) function in D-gal-triggered aging porcine SCs and mouse model testes, according to in vitro and in vivo experiments. Furthermore, rapamycin, NAC, MCC950, and IL-1Ra restored the TJ function in D-gal-stimulated aging porcine SCs, while BMSC-Exos' stimulatory effect on TJ function was inhibited by chloroquine. Moreover, the treatment with BMSC-Exos enhanced autophagy in D-gal-induced aging porcine SCs by means of the AMPK/mTOR signal transduction pathway. These findings uncovered through the present study that BMSC-Exos can enhance the BTB function in aging testes by improving autophagy via the AMPK/mTOR signaling pathway, thereby suppressing ROS production and NLRP3 inflammasome activation.

Indexed as

autophagyblood-testis barrierBMSC-Exossenescencetight junction

Identifiers

PMID38397781
PMCPMC10886345
OpenAlexW4391450347

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.