ArticleAntioxidants (Basel, Switzerland)2024
The Antioxidant Mechanism of Peptides Extracted from Tuna Protein Revealed Using a Molecular Docking Simulation.
Article in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Green and Energy-Efficient Post-Harvest Enhancement: Low-DoseAntioxidants (Basel, Switzerland) · 2026Article
- Bioinformatic Identification and Experimental Validation of Novel Antioxidant Peptides Derived from Salmon Collagen.Foods (Basel, Switzerland) · 2026Article
- Characterization, Identification, and Antioxidant Mechanism of Antioxidant Peptides FromFood science & nutrition · 2026Article
- Novel antioxidant peptides from chicken bone hydrolysate: Identification, structure-activity relationship and cytoprotective effects against oxidative stress in HaCaT cells.Food chemistry: X · 2026Article
- Immunomodulatory Peptides Derived fromFoods (Basel, Switzerland) · 2026Article
- Rational Design of PCR12mod6, a Cathelicidin-HR-Derived Peptide with Enhanced Dual-Action Antimicrobial and Antioxidant Activity.ACS omega · 2025Article
- Identification and Screening of Novel Antioxidant Peptides from Yak Skin and Their Protective Effect on HInternational journal of molecular sciences · 2025Article
- Marine Peptides: Potential Basic Structures for the Development of Hybrid Compounds as Multitarget Therapeutics for the Treatment of Multifactorial Diseases.International journal of molecular sciences · 2024Review
- Research Progress on Antioxidant Peptides from Fish By-Products: Purification, Identification, and Structure-Activity Relationship.Metabolites · 2024Review
- Novel Antioxidant Self-Assembled Peptides Extracted fromAntioxidants (Basel, Switzerland) · 2024Article
- Evaluation of nutrient composition and bone-promoting activity of miiuy croaker (Frontiers in nutrition · 2024Article
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Authors and funding
5 authors.
Funding
Abstract
Tuna protein serves as a significant source of bioactive peptides, and its functional properties can be elucidated through predictive modeling, followed by experimental validation. In this study, the active polypeptides were obtained from tuna protein via enzymatic hydrolysis (TPP), and their peptide sequences were determined. Furthermore, the potential activity of these peptides was predicted, focusing on antioxidant peptides, and compared to the sequence library of known antioxidant peptides to identify common structural motifs. The accuracy of the prediction results was confirmed through in vitro antioxidant assays and molecular docking studies. We identified seven specific peptide segments derived from tuna protein that exhibit antioxidant potential, accounting for approximately 15% of all active peptides. Molecular docking and cell experiments were employed to provide compelling evidence for the presence of antioxidant peptides within tuna protein. This study not only lays a solid foundation for studying the structure of active peptides but also opens up a novel avenue for an expedited assessment of their properties.
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