Evidence map›Paper›PMID 38397737›Full record

ReviewAntioxidants (Basel, Switzerland)2024

Acetic Acid: An Underestimated Metabolite in Ethanol-Induced Changes in Regulating Cardiovascular Function.

Andrew D Chapp, Zhiying Shan, Qing-Hui Chen

Open access · goldAbstract readReview
In one paragraph

Review in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.7field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Andrew D ChappDepartment of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
Zhiying ShanKinesiology and Integrative Physiology, Michigan Technological University, Houghton, MI 49931, USA.ORCID 0000-0002-9763-205X
Qing-Hui ChenKinesiology and Integrative Physiology, Michigan Technological University, Houghton, MI 49931, USA.ORCID 0000-0002-1639-5292
Michigan Technological University · USUniversity of Minnesota · US

Funding

Contribution of Orexin System to HypertensionR01HL163159 · NHLBI · MICHIGAN TECHNOLOGICAL UNIVERSITY · PI SHAN, ZHIYING · 2022 to 2025
$1.7M
ER stress and reduced SK channel function in PVN in rats with high salt intakeR15HL122952 · NHLBI · MICHIGAN TECHNOLOGICAL UNIVERSITY · PI CHEN, QING-HUI H · 2015 to 2015
$459k
NHLBI NIH HHS R01 HL163159NHLBI NIH HHS R15 HL122952NIH HHS NIHR01HL163159NIH HHS NIHR15HL122952
6 · The paper itself

Abstract

Acetic acid is a bioactive short-chain fatty acid produced in large quantities from ethanol metabolism. In this review, we describe how acetic acid/acetate generates oxidative stress, alters the function of pre-sympathetic neurons, and can potentially influence cardiovascular function in both humans and rodents after ethanol consumption. Our recent findings from in vivo and in vitro studies support the notion that administration of acetic acid/acetate generates oxidative stress and increases sympathetic outflow, leading to alterations in arterial blood pressure. Real-time investigation of how ethanol and acetic acid/acetate modulate neural control of cardiovascular function can be conducted by microinjecting compounds into autonomic control centers of the brain and measuring changes in peripheral sympathetic nerve activity and blood pressure in response to these compounds.

Indexed as

acetateacetic acidcardiovascular functionethanolnitric oxidesympathetic nerve activity

Identifiers

PMID38397737
PMCPMC10886048
OpenAlexW4391137756

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.