Evidence map›Paper›PMID 38397624›Full record

ArticleInternational journal of environmental research and public health2024

Determinants of HIV Pre-Exposure Prophylaxis (PrEP) Retention among Transgender Women: A Sequential, Explanatory Mixed Methods Study.

Jack Andrzejewski, Heather A Pines, Sheldon Morris, Leah Burke, Robert Bolan, Jae Sevelius, David J Moore, Jill Blumenthal

Abstract read
In one paragraph

Article in International journal of environmental research and public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Article
  3. Retention of clients in HIV oral pre-exposure prophylaxis care in Engela, Namibia.African journal of primary health care & family medicine · 2025
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jack AndrzejewskiSan Diego Joint Doctoral Program in Public Health, San Diego State University-University of California San Diego, San Diego, CA 92093, USA.ORCID 0000-0002-3109-9774
Heather A PinesSchool of Public Health, San Diego State University, San Diego, CA 92182, USA.
Sheldon MorrisDepartment of Medicine, University of California San Diego, La Jolla, CA 92161, USA.
Leah BurkeDepartment of Medicine, University of California San Diego, La Jolla, CA 92161, USA.
Robert BolanLA LGBT Center, Los Angeles, CA 90038, USA.
Jae SeveliusDepartment of Psychiatry, Columbia University, New York, NY 10032, USA.
David J MooreDepartment of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.
Jill BlumenthalDepartment of Medicine, University of California San Diego, La Jolla, CA 92161, USA.

Funding

VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUSAN JANET LITTLE · 1994 to 2026
$78.4M
Mentoring clinical investigators in patient-oriented research on substance use and HIVK24DA051328 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SEVELIUS, JAE M. · 2020 to 2024
$771k
NIAID NIH HHS P30 AI036214NIDA NIH HHS K24 DA051328
6 · The paper itself

Abstract

Transgender women (TW) face inequities in HIV and unique barriers to PrEP, an effective biomedical intervention to prevent HIV acquisition. To improve PrEP retention among TW, we examined factors related to retention using a two-phase, sequential explanatory mixed methods approach. In Phase I, we used data from a trial of 170 TW who were provided oral PrEP to examine predictors of 24-week retention. In Phase II, we conducted 15 in-depth interviews with PrEP-experienced TW and used thematic analysis to explain Phase I findings. In Phase I, more participants who were not retained at 24 weeks reported sex work engagement (18% versus 7%) and substantial/severe drug use (18% versus 8%). In Phase II, participants reported drug use as a barrier to PrEP, often in the context of sex work, and we identified two subcategories of sex work. TW engaged in "non-survival sex work" had little difficulty staying on PrEP, while those engaged in "survival sex work" struggled to stay on PrEP. In Phase I, fewer participants not retained at 24 weeks reported gender-affirming hormone therapy (GAHT) use (56% versus 71%). In Phase II, participants prioritized medical gender affirmation services over PrEP but also described the bidirectional benefits of accessing GAHT and PrEP. TW who engaged in "survival sex work" experience barriers to PrEP retention (e.g., unstable housing, drug use) and may require additional support to stay in PrEP care.

Indexed as

Anti-HIV AgentsHIV InfectionsPre-Exposure ProphylaxisTransgender PersonsTranssexualismFemaleHumansMaleAnti-HIV Agentsgender affirmationHIVPrEPsex worksubstance usetransgender women

Identifiers

PMID38397624
PMCPMC10888369

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.