Evidence map›Paper›PMID 38397463›Full record

ArticleBiomolecules2024

Antimicrobial Potency of Fmoc-Phe-Phe Dipeptide Hydrogels with Encapsulated Porphyrin Chromophores Is a Promising Alternative in Antimicrobial Resistance.

Chrysanthi Pinelopi Apostolidou, Chrysoula Kokotidou, Varvara Platania, Vasilis Nikolaou, Georgios Landrou, Emmanouil Nikoloudakis, Georgios Charalambidis, Maria Chatzinikolaidou, Athanassios G Coutsolelos, Anna Mitraki

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Self-Assembly Properties of Xylene-Derived Constitutional Isomers of Fmoc-Phenylalanine.Langmuir : the ACS journal of surfaces and colloids · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Chrysanthi Pinelopi ApostolidouDepartment of Materials Science and Technology, University of Crete, Voutes Campus, 71003 Heraklion, Greece.
Chrysoula KokotidouDepartment of Materials Science and Technology, University of Crete, Voutes Campus, 71003 Heraklion, Greece.ORCID 0000-0003-4825-9022
Varvara PlataniaDepartment of Materials Science and Technology, University of Crete, Voutes Campus, 71003 Heraklion, Greece.
Vasilis NikolaouLaboratory of Bioinorganic Chemistry, Department of Chemistry, University of Crete, Voutes Campus, 70013 Heraklion, Greece.ORCID 0000-0001-9724-9248
Georgios LandrouLaboratory of Bioinorganic Chemistry, Department of Chemistry, University of Crete, Voutes Campus, 70013 Heraklion, Greece.
Emmanouil NikoloudakisLaboratory of Bioinorganic Chemistry, Department of Chemistry, University of Crete, Voutes Campus, 70013 Heraklion, Greece.
Georgios CharalambidisLaboratory of Bioinorganic Chemistry, Department of Chemistry, University of Crete, Voutes Campus, 70013 Heraklion, Greece.ORCID 0000-0003-1237-9962
Maria ChatzinikolaidouDepartment of Materials Science and Technology, University of Crete, Voutes Campus, 71003 Heraklion, Greece.ORCID 0000-0002-2749-2506
Athanassios G CoutsolelosInstitute of Electronic Structure and Laser (IESL) FORTH, 70013 Heraklion, Greece.ORCID 0000-0001-5682-2968
Anna MitrakiDepartment of Materials Science and Technology, University of Crete, Voutes Campus, 71003 Heraklion, Greece.
University of Crete · GR

Funding

European Regional Development Fund of the European Union and Greek national funds T1EDK - 01504
6 · The paper itself

Abstract

Antimicrobial resistance (AMR) poses a significant global health risk as a consequence of misuse of antibiotics. Owing to the increasing antimicrobial resistance, it became imperative to develop novel molecules and materials with antimicrobial properties. Porphyrins and metalloporphyrins are compounds which present antimicrobial properties especially after irradiation. As a consequence, porphyrinoids have recently been utilized as antimicrobial agents in antimicrobial photodynamic inactivation in bacteria and other microorganisms. Herein, we report the encapsulation of porphyrins into peptide hydrogels which serve as delivery vehicles. We selected the self-assembling Fmoc-Phe-Phe dipeptide, a potent gelator, as a scaffold due to its previously reported biocompatibility and three different water-soluble porphyrins as photosensitizers. We evaluated the structural, mechanical and

Indexed as

Anti-Infective AgentsFluorenesPorphyrinsAnimalsAnti-Bacterial AgentsDipeptidesDrug Resistance, BacterialEscherichia coliHydrogelsMiceNIH 3T3 CellsStaphylococcus aureusAnti-Bacterial AgentsAnti-Infective AgentsDipeptidesFluorenesfluorenyl-9-methoxycarbonyl diphenylalanineHydrogelsPorphyrinsantimicrobial activitycontrolled releaseencapsulationhydrogelsphotodynamic inactivationporphyrinsself-assembling peptides

Identifiers

PMID38397463
PMCPMC10887087
OpenAlexW4391882448

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.