Evidence map›Paper›PMID 38397376›Full record

ArticleBiomolecules2024

The Osteoblast Transcriptome in Developing Zebrafish Reveals Key Roles for Extracellular Matrix Proteins Col10a1a and Fbln1 in Skeletal Development and Homeostasis.

Ratish Raman, Mishal Antony, Renaud Nivelle, Arnaud Lavergne, Jérémie Zappia, Gustavo Guerrero-Limón, Caroline Caetano da Silva, Priyanka Kumari, Jerry Maria Sojan, Christian Degueldre and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Mitigation of PFOA-Induced Developmental Toxicity inInternational journal of molecular sciences · 2025
    Article
  5. Modulation of the gut-bone axis:Frontiers in immunology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 3 countries.

Ratish RamanLaboratory for Organogenesis and Regeneration (LOR), GIGA Institute, University of Liège, 4000 Liège, Belgium.ORCID 0000-0002-2187-9216
Mishal AntonyLaboratory for Organogenesis and Regeneration (LOR), GIGA Institute, University of Liège, 4000 Liège, Belgium.ORCID 0009-0002-3537-382X
Renaud NivelleLaboratory for Organogenesis and Regeneration (LOR), GIGA Institute, University of Liège, 4000 Liège, Belgium.
Arnaud LavergneGIGA Genomics Platform, B34, GIGA Institute, University of Liège, 4000 Liège, Belgium.
Jérémie ZappiaMusculoSKeletal Innovative Research Lab, Center for Interdisciplinary Research on Medicines, University of Liège, 4000 Liège, Belgium.ORCID 0000-0001-9987-3626
Gustavo Guerrero-LimónLaboratory for Organogenesis and Regeneration (LOR), GIGA Institute, University of Liège, 4000 Liège, Belgium.ORCID 0000-0002-3197-5500
Caroline Caetano da SilvaHospital Lariboisière, Reference Centre for Rare Bone Diseases, INSERM U1132, Université de Paris-Cité, F-75010 Paris, France.ORCID 0000-0001-9044-7348
Priyanka KumariLaboratory of Pharmaceutical and Analytical Chemistry, Department of Pharmacy, CIRM, Sart Tilman, 4000 Liège, Belgium.
Jerry Maria SojanDepartment of Life and Environmental Sciences, Università Politecnica delle Marche, Via Brecce Bianche, 60131 Ancona, Italy.
Christian DegueldreGIGA CRC In Vivo Imaging, University of Liège, Sart Tilman, 4000 Liège, Belgium.ORCID 0000-0002-9058-4390
Mohamed Ali BahriGIGA CRC In Vivo Imaging, University of Liège, Sart Tilman, 4000 Liège, Belgium.ORCID 0000-0002-6919-3360
Agnes OstertagHospital Lariboisière, Reference Centre for Rare Bone Diseases, INSERM U1132, Université de Paris-Cité, F-75010 Paris, France.ORCID 0000-0002-1966-3213
Corinne ColletHospital Lariboisière, Reference Centre for Rare Bone Diseases, INSERM U1132, Université de Paris-Cité, F-75010 Paris, France.
Martine Cohen-SolalHospital Lariboisière, Reference Centre for Rare Bone Diseases, INSERM U1132, Université de Paris-Cité, F-75010 Paris, France.ORCID 0000-0002-8582-8258
Alain PlenevauxGIGA CRC In Vivo Imaging, University of Liège, Sart Tilman, 4000 Liège, Belgium.
Yves HenrotinMusculoSKeletal Innovative Research Lab, Center for Interdisciplinary Research on Medicines, University of Liège, 4000 Liège, Belgium.
Jörg RennLaboratory for Organogenesis and Regeneration (LOR), GIGA Institute, University of Liège, 4000 Liège, Belgium.
Marc MullerLaboratory for Organogenesis and Regeneration (LOR), GIGA Institute, University of Liège, 4000 Liège, Belgium.ORCID 0000-0001-6030-2164
University of Liège · BEInserm · FRMarche Polytechnic University · IT

Funding

European Union EU MSCA-ITN project BioMedAqu GA 766347
6 · The paper itself

Abstract

Zebrafish are now widely used to study skeletal development and bone-related diseases. To that end, understanding osteoblast differentiation and function, the expression of essential transcription factors, signaling molecules, and extracellular matrix proteins is crucial. We isolated Sp7-expressing osteoblasts from 4-day-old larvae using a fluorescent reporter. We identified two distinct subpopulations and characterized their specific transcriptome as well as their structural, regulatory, and signaling profile. Based on their differential expression in these subpopulations, we generated mutants for the extracellular matrix protein genes

Indexed as

Collagen Type XExtracellular Matrix ProteinsOsteoblastsZebrafishAnimalsCalcium-Binding ProteinsCell DifferentiationExtracellular MatrixHomeostasisMineralsTranscriptomeCalcium-Binding ProteinsCollagen Type XExtracellular Matrix ProteinsfibulinMineralscol10a1aECMfbln1FGF8gene expressionosteoblastskeletal developmenttranscriptomevertebrazebrafish

Identifiers

PMID38397376
PMCPMC10886564
OpenAlexW4391139566

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.