ArticleChildren (Basel, Switzerland)2024
Comorbidities and Disease Duration in Tourette Syndrome: Impact on Cognition and Quality of Life of Children.
Article in Children (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- From prediction to action: developing a risk-stratified management tool for children with new-onset tic disorders.Scientific reports · 2026Article
- Tic severity and quality of life in children with tic disorders: the chain mediating effects of stigma and anxiety.Frontiers in psychiatry · 2026Article
- Tic severity and executive functioning in children and adolescents: a moderated mediation model of premonitory urges and comorbidity.Child and adolescent psychiatry and mental health · 2025Article
- Clinical symptoms and functional impairment in attention deficit hyperactivity disorder (ADHD) co-morbid tic disorder (TD) patients: a cluster-based investigation.BMC psychiatry · 2025Article
- Growing up with tic disorders: an Italian survey on quality of life and access to care.Frontiers in psychiatry · 2025Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCognitive functions represent foundational factors for mental health and quality of life (QoL). In Tourette syndrome (TS), psychiatric comorbidities are common and have been inconsistently reported to affect the cognition and QoL of patients, while the role of tic disorder duration has not been yet explored.
methodsTo examine how comorbidities and TS duration may influence cognition and QoL,
resultsDepression and attention-deficit/hyperactivity disorder (ADHD) symptoms accounted for poorer cognitive performance. Anxiety oppositely predicted better cognitive performance, while no significant role for obsessive compulsive disorder (OCD) was observed. Disease duration was associated with lower total IQ, verbal reasoning, and working memory abilities. Depression, anxiety, and TS duration also deeply influenced QoL measures.
conclusionsTS common comorbidities have a differential impact on the cognitive abilities of children and adolescents, which translates into a complex influence on their perceived QoL. A longer clinical history of tics was related to worse cognitive outcomes, which prompts further consideration of disease duration in both clinical and research settings involving children and adolescents.
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