Evidence map›Paper›PMID 38397143›Full record

ArticleGenes2024

Cognitive Function Is Associated with the Genetically Determined Efficiency of DNA Repair Mechanisms.

Nicolas Cherbuin, Hardip Patel, Erin I Walsh, Ananthan Ambikairajah, Richard Burns, Anne Brüstle, Lene Juel Rasmussen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Nicolas CherbuinNational Centre for Epidemiology and Population Health, Australian National University, Canberra 2601, Australia.ORCID 0000-0001-6481-0748
Hardip PatelJohn Curtin School of Medical Research, Australian National University, Canberra 2601, Australia.
Erin I WalshNational Centre for Epidemiology and Population Health, Australian National University, Canberra 2601, Australia.ORCID 0000-0001-8941-0046
Ananthan AmbikairajahNational Centre for Epidemiology and Population Health, Australian National University, Canberra 2601, Australia.ORCID 0000-0002-5808-8020
Richard BurnsNational Centre for Epidemiology and Population Health, Australian National University, Canberra 2601, Australia.
Anne BrüstleJohn Curtin School of Medical Research, Australian National University, Canberra 2601, Australia.ORCID 0000-0002-3842-5683
Lene Juel RasmussenDepartment of Cellular and Molecular Medicine, Center for Healthy Aging, University of Copenhagen, 2200 Copenhagen, Denmark.ORCID 0000-0001-6864-963X
Australian National University · AUUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several modifiable risk factors for neurodegeneration and dementia have been identified, although individuals vary in their vulnerability despite a similar risk of exposure. This difference in vulnerability could be explained at least in part by the variability in DNA repair mechanisms' efficiency between individuals. Therefore, the aim of this study was to test associations between documented, prevalent genetic variation (single nucleotide polymorphism, SNP) in DNA repair genes, cognitive function, and brain structure. Community-living participants (

Indexed as

DementiaDNA GlycosylasesCognitionDNA-(Apurinic or Apyrimidinic Site) LyaseDNA RepairFemaleHumansMaleMiddle AgedDNA-(Apurinic or Apyrimidinic Site) LyaseDNA GlycosylasesNEIL1 protein, humanbrain ageingcognitive declineDNA repairinflammationoxidative stresssingle nucleotide polymorphism

Identifiers

PMID38397143
PMCPMC10888195
OpenAlexW4391167651

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.