Evidence map›Paper›PMID 38397090›Full record

ArticleInternational journal of molecular sciences2024

Ex Vivo Optimization of Donor Lungs with Inhaled Sevoflurane during Normothermic Ex Vivo Lung Perfusion (VITALISE): A Pilot and Feasibility Study in Sheep.

Timo Steinkühler, Shuqi Yang, Michiel A Hu, Jayant S Jainandunsing, Neeltina M Jager, Michiel E Erasmus, Michel M R F Struys, Dirk J Bosch, Matijs van Meurs, Matthieu Jabaudon and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 3 countries.

Timo SteinkühlerDepartment of Anesthesiology, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0009-0008-8385-5376
Shuqi YangDepartment of Anesthesiology, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0000-0002-0617-4701
Michiel A HuDepartment of Thoracic Surgery, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.
Jayant S JainandunsingDepartment of Anesthesiology, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.
Neeltina M JagerDepartment of Anesthesiology, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.
Michiel E ErasmusDepartment of Thoracic Surgery, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.
Michel M R F StruysDepartment of Anesthesiology, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.
Dirk J BoschDepartment of Anesthesiology, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.
Matijs van MeursDepartment of Critical Care, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.
Matthieu JabaudonDepartment of Perioperative Medicine, University Hospital Clermont-Ferrand, 63001 Clermont-Ferrand, France.ORCID 0000-0002-8121-1680
Damien RichardDepartment of Pharmacology and Toxicology, University Hospital Clermont-Ferrand, University Clermont Auvergne, 63001 Clermont-Ferrand, France.
Wim TimensDepartment of Pathology and Medical Biology, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0000-0002-4146-6363
Henri G D LeuveninkDepartment of Surgery, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.
Gertrude J Nieuwenhuijs-MoekeDepartment of Anesthesiology, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0000-0001-9874-2632
University Medical Center Groningen · NLCentre National de la Recherche Scientifique · FRUniversité Clermont Auvergne · FR

Funding

This project was supported by a medical research grant from Sedana Medical (Danderdyd, Sweden), who provided 12 Sedconda devices, 25 Sedaconda syringes and 1 filling adapter. This study was further supported by the University Medical Centre Groningen tran n.a.
6 · The paper itself

Abstract

Volatile anesthetics have been shown in different studies to reduce ischemia reperfusion injury (IRI). Ex vivo lung perfusion (EVLP) facilitates graft evaluation, extends preservation time and potentially enables injury repair and improvement of lung quality. We hypothesized that ventilating lungs with sevoflurane during EVLP would reduce lung injury and improve lung function. We performed a pilot study to test this hypothesis in a slaughterhouse sheep DCD model. Lungs were harvested, flushed and stored on ice for 3 h, after which EVLP was performed for 4 h. Lungs were ventilated with either an FiO

Indexed as

Lung TransplantationAnimalsFeasibility StudiesLungOrgan PreservationPerfusionPilot ProjectsSevofluraneSheepSevofluraneanesthesiaex vivo lung perfusionischemia reperfusion injurylung transplantationsevofluranevolatile anesthetics

Identifiers

PMID38397090
PMCPMC10888671
OpenAlexW4391930901

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.