Evidence map›Paper›PMID 38397074›Full record

ArticleInternational journal of molecular sciences2024

Pharmacological Activation of TRPC6 Channel Prevents Colitis Progression.

Kazuhiro Nishiyama, Yuri Kato, Akiyuki Nishimura, Xinya Mi, Ryu Nagata, Yasuo Mori, Yasu-Taka Azuma, Motohiro Nishida

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Kazuhiro NishiyamaGraduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Yuri KatoGraduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.ORCID 0000-0002-9426-911X
Akiyuki NishimuraNational Institute for Physiological Sciences (NIPS), National Institutes of Natural Sciences, Okazaki 444-8787, Japan.ORCID 0000-0003-2309-3994
Xinya MiGraduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Ryu NagataGraduate School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, Japan.
Yasuo MoriGraduate School of Engineering, Kyoto University, Kyoto 615-8530, Japan.
Yasu-Taka AzumaLaboratory of Prophylactic Pharmacology, Osaka Metropolitan University Graduate School of Veterinary Science, Osaka 598-8531, Japan.ORCID 0000-0002-3515-171X
Motohiro NishidaGraduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.ORCID 0000-0002-2587-5458
Kyushu University · JPKyoto University · JPNational Institutes of Natural Sciences · JPOsaka Metropolitan University · JPOsaka University of Pharmaceutical Sciences · JP

Funding

Japan Science and Technology Agency JPMJCR2024Japan Society for the Promotion of Science 21H05269Japan Society for the Promotion of Science 22H02772Japan Society for the Promotion of Science 22H04814Japan Society for the Promotion of Science 22K06630Japan Society for the Promotion of Science 22K19395Naito (Japan) The Naito FoundationPlatform Project for Supporting Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS)) from AMED JP23ama121031Takeda (Japan) Takeda Science Foundation
6 · The paper itself

Abstract

We recently reported that transient receptor potential canonical (TRPC) 6 channel activity contributes to intracellular Zn

Indexed as

Inflammatory Bowel DiseasesTRPC6 Cation ChannelAnimalsColonDextran SulfateDisease Models, AnimalHumansIntestinesMiceMice, Inbred C57BLRNA, MessengerDextran SulfateRNA, MessengerTRPC6 Cation ChannelTRPC6 protein, humancanonical transient receptor potential 6colitisgut microbiotastress resistance

Identifiers

PMID38397074
PMCPMC10889536
OpenAlexW4391945588

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.