Evidence map›Paper›PMID 38397066›Full record

ArticleInternational journal of molecular sciences2024

Nanostructured Coatings Based on Graphene Oxide for the Management of Periprosthetic Infections.

Sorin Constantinescu, Adelina-Gabriela Niculescu, Ariana Hudiță, Valentina Grumezescu, Dragoș Rădulescu, Alexandra Cătălina Bîrcă, Gabriela Dorcioman, Oana Gherasim, Alina Maria Holban, Bianca Gălățeanu and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Sorin ConstantinescuFaculty of Medicine, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Street, 050474 Bucharest, Romania.
Adelina-Gabriela NiculescuResearch Institute of the University of Bucharest-ICUB, University of Bucharest, 90-92 Panduri, 050663 Bucharest, Romania.ORCID 0000-0001-8968-504X
Ariana HudițăResearch Institute of the University of Bucharest-ICUB, University of Bucharest, 90-92 Panduri, 050663 Bucharest, Romania.ORCID 0000-0002-9439-9432
Valentina GrumezescuLasers Department, National Institute for Lasers, Plasma and Radiation Physics, 409 Atomistilor Street, 077125 Magurele, Romania.
Dragoș RădulescuFaculty of Medicine, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Street, 050474 Bucharest, Romania.
Alexandra Cătălina BîrcăDepartment of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 1-7 Gh. Polizu Street, 060042 Bucharest, Romania.
Gabriela DorciomanLasers Department, National Institute for Lasers, Plasma and Radiation Physics, 409 Atomistilor Street, 077125 Magurele, Romania.ORCID 0000-0002-8323-9150
Oana GherasimLasers Department, National Institute for Lasers, Plasma and Radiation Physics, 409 Atomistilor Street, 077125 Magurele, Romania.
Alina Maria HolbanResearch Institute of the University of Bucharest-ICUB, University of Bucharest, 90-92 Panduri, 050663 Bucharest, Romania.
Bianca GălățeanuDepartment of Biochemistry and Molecular Biology, University of Bucharest, 91-95 Splaiul Independentei Street, 050095 Bucharest, Romania.ORCID 0000-0001-8093-1750
Bogdan Ștefan VasileDepartment of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 1-7 Gh. Polizu Street, 060042 Bucharest, Romania.ORCID 0000-0002-2267-6453
Alexandru Mihai GrumezescuResearch Institute of the University of Bucharest-ICUB, University of Bucharest, 90-92 Panduri, 050663 Bucharest, Romania.ORCID 0000-0003-3036-094X
Alexandra BolocanFaculty of Medicine, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Street, 050474 Bucharest, Romania.
Radu RădulescuFaculty of Medicine, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Street, 050474 Bucharest, Romania.
University of Bucharest · ROCarol Davila University of Medicine and Pharmacy · RONational Institute for Laser Plasma and Radiation Physics · ROUniversitatea Națională de Știință și Tehnologie Politehnica București · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To modulate the bioactivity and boost the therapeutic outcome of implantable metallic devices, biodegradable coatings based on polylactide (PLA) and graphene oxide nanosheets (nGOs) loaded with Zinforo™ (Zin) have been proposed in this study as innovative alternatives for the local management of biofilm-associated periprosthetic infections. Using a modified Hummers protocol, high-purity and ultra-thin nGOs have been obtained, as evidenced by X-ray diffraction (XRD) and transmission electron microscopy (TEM) investigations. The matrix-assisted pulsed laser evaporation (MAPLE) technique has been successfully employed to obtain the PLA-nGO-Zin coatings. The stoichiometric and uniform transfer was revealed by infrared microscopy (IRM) and scanning electron microscopy (SEM) studies. In vitro evaluation, performed on fresh blood samples, has shown the excellent hemocompatibility of PLA-nGO-Zin-coated samples (with a hemolytic index of 1.15%), together with their anti-inflammatory ability. Moreover, the PLA-nGO-Zin coatings significantly inhibited the development of mature bacterial biofilms, inducing important anti-biofilm efficiency in the as-coated samples. The herein-reported results evidence the promising potential of PLA-nGO-Zin coatings to be used for the biocompatible and antimicrobial surface modification of metallic implants.

Indexed as

Anti-Infective AgentsGraphiteNanostructuresCoated Materials, BiocompatiblePolyestersAnti-Infective AgentsCoated Materials, Biocompatiblegraphene oxideGraphitePolyestersanti-biofilm efficiencygraphene oxidehemocompatible coatingsMAPLEnanostructured coatingspolylactide (PLA)

Identifiers

PMID38397066
PMCPMC10889398
OpenAlexW4391945030

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.