Evidence map›Paper›PMID 38397052›Full record

ArticleInternational journal of molecular sciences2024

Alterations in Genome Organization in Lymphoma Cell Nuclei due to the Presence of the t(14;18) Translocation.

Elisa Garimberti, Concetta Federico, Denise Ragusa, Francesca Bruno, Salvatore Saccone, Joanna Mary Bridger, Sabrina Tosi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Elisa GarimbertiClinical Genomics Laboratory, Royal Marsden NHS Foundation Trust, London SW3 6JJ, UK.
Concetta FedericoDepartment of Biological, Geological, and Environmental Sciences, University of Catania, Via Androne 81, 95124 Catania, Italy.ORCID 0000-0002-0160-9040
Denise RagusaCentre for Genome Engineering and Maintenance (CenGEM), College of Health, Medicine and Life Sciences, Brunel University London, Kingston Lane, Uxbridge UB8 3PH, UK.ORCID 0000-0002-0303-8683
Francesca BrunoDepartment of Biological, Geological, and Environmental Sciences, University of Catania, Via Androne 81, 95124 Catania, Italy.ORCID 0000-0003-2704-0013
Salvatore SacconeDepartment of Biological, Geological, and Environmental Sciences, University of Catania, Via Androne 81, 95124 Catania, Italy.ORCID 0000-0001-7568-5823
Joanna Mary BridgerCentre for Genome Engineering and Maintenance (CenGEM), College of Health, Medicine and Life Sciences, Brunel University London, Kingston Lane, Uxbridge UB8 3PH, UK.ORCID 0000-0003-3999-042X
Sabrina TosiCentre for Genome Engineering and Maintenance (CenGEM), College of Health, Medicine and Life Sciences, Brunel University London, Kingston Lane, Uxbridge UB8 3PH, UK.ORCID 0000-0002-0036-0191
Brunel University of London · GBUniversity of Catania · ITRoyal Marsden NHS Foundation Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chromosomal rearrangements have been shown to alter genome organization, consequently having an impact on gene expression. Studies on certain types of leukemia have shown that gene expression can be exacerbated by the altered nuclear positioning of fusion genes arising from chromosomal translocations. However, studies on lymphoma have been, so far, very limited. The scope of this study was to explore genome organization in lymphoma cells carrying the t(14;18)(q32;q21) rearrangement known to results in over-expression of the

Indexed as

LymphomaTranslocation, GeneticCell NucleusHumansIn Situ Hybridization, FluorescenceProto-Oncogene Proteins c-bcl-2Proto-Oncogene Proteins c-bcl-218)BCL2chromosomal translocationchromosome loopingchromosomesfluorescence in situ hybridizationgenome organizationIGHlymphomanuclear gene positioningt(14

Identifiers

PMID38397052
PMCPMC10889133
OpenAlexW4391927033

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.