Evidence map›Paper›PMID 38397022›Full record

ArticleInternational journal of molecular sciences2024

Unearthing a Cryptic Biosynthetic Gene Cluster for the Piperazic Acid-Bearing Depsipeptide Diperamycin in the Ant-Dweller

Coral García-Gutiérrez, Ignacio Pérez-Victoria, Ignacio Montero, Jorge Fernández-De la Hoz, Mónica G Malmierca, Jesús Martín, José A Salas, Carlos Olano, Fernando Reyes, Carmen Méndez

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Coral García-GutiérrezDepartamento de Biología Funcional e Instituto Universitario de Oncología del Principado de Asturias (I.U.O.P.A), Universidad de Oviedo, 33006 Oviedo, Spain.ORCID 0000-0001-7105-5138
Ignacio Pérez-VictoriaFundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, 18016 Granada, Spain.ORCID 0000-0002-4556-688X
Ignacio MonteroDepartamento de Biología Funcional e Instituto Universitario de Oncología del Principado de Asturias (I.U.O.P.A), Universidad de Oviedo, 33006 Oviedo, Spain.ORCID 0000-0002-7982-3477
Jorge Fernández-De la HozDepartamento de Biología Funcional e Instituto Universitario de Oncología del Principado de Asturias (I.U.O.P.A), Universidad de Oviedo, 33006 Oviedo, Spain.ORCID 0000-0002-6047-6532
Mónica G MalmiercaDepartamento de Biología Funcional e Instituto Universitario de Oncología del Principado de Asturias (I.U.O.P.A), Universidad de Oviedo, 33006 Oviedo, Spain.
Jesús MartínFundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, 18016 Granada, Spain.
José A SalasDepartamento de Biología Funcional e Instituto Universitario de Oncología del Principado de Asturias (I.U.O.P.A), Universidad de Oviedo, 33006 Oviedo, Spain.ORCID 0000-0001-6495-3810
Carlos OlanoDepartamento de Biología Funcional e Instituto Universitario de Oncología del Principado de Asturias (I.U.O.P.A), Universidad de Oviedo, 33006 Oviedo, Spain.ORCID 0000-0001-5440-3540
Fernando ReyesFundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, 18016 Granada, Spain.ORCID 0000-0003-1607-5106
Carmen MéndezDepartamento de Biología Funcional e Instituto Universitario de Oncología del Principado de Asturias (I.U.O.P.A), Universidad de Oviedo, 33006 Oviedo, Spain.ORCID 0000-0003-2729-841X
Universidad de Oviedo · ESFundación Medina · ES

Funding

Spanish Ministry of Economy and Competitiveness BIO2017-82462-RSpanish Ministry of Science and Competitiveness PID2020-113062RB-100Spanish Ministry of Science, Innovation, and Universities RTI2018-093562-B-I00
6 · The paper itself

Abstract

Piperazic acid is a cyclic nonproteinogenic amino acid that contains a hydrazine N-N bond formed by a piperazate synthase (KtzT-like). This amino acid, found in bioactive natural products synthesized by non-ribosomal peptide synthetases (NRPSs), confers conformational constraint to peptides, an important feature for their biological activities. Genome mining of

Indexed as

DepsipeptidesPyridazinesStreptomycesAmino AcidsAntimicrobial Cationic PeptidesMultigene FamilyPolyketide SynthasesAmino AcidsAntimicrobial Cationic PeptidesDepsipeptidesdiperamycinpiperazic acidPolyketide SynthasesPyridazinesazinothricindepsipeptidediperamycingenome mininghydrazinenatural productsN-N bondNRPSpiperazatePKSsecondary metabolitesStreptomyces

Identifiers

PMID38397022
PMCPMC10888640
OpenAlexW4391883374

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.