Evidence map›Paper›PMID 38396887›Full record

ArticleInternational journal of molecular sciences2024

Evaluating the Effects of Kidney Preservation at 10 °C with Hemopure and Sodium Thiosulfate in a Rat Model of Syngeneic Orthotopic Kidney Transplantation.

Maria Abou Taka, George J Dugbartey, Mahms Richard-Mohamed, Patrick McLeod, Jifu Jiang, Sally Major, Jacqueline Arp, Caroline O'Neil, Winnie Liu, Manal Gabril and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Maria Abou TakaDepartment of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada.ORCID 0000-0002-7272-3916
George J DugbarteyMatthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON N6A 5A5, Canada.ORCID 0000-0001-8161-7202
Mahms Richard-MohamedMatthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON N6A 5A5, Canada.ORCID 0000-0001-5920-6511
Patrick McLeodMatthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON N6A 5A5, Canada.
Jifu JiangMatthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON N6A 5A5, Canada.
Sally MajorMatthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON N6A 5A5, Canada.
Jacqueline ArpMatthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON N6A 5A5, Canada.
Caroline O'NeilThe Molecular Pathology Core, Robarts Research Institute, London, ON N6A 5A5, Canada.
Winnie LiuLondon Health Sciences Centre, Department of Pathology and Laboratory Medicine, London, ON N6A 5A5, Canada.
Manal GabrilLondon Health Sciences Centre, Department of Pathology and Laboratory Medicine, London, ON N6A 5A5, Canada.
Madeleine MoussaLondon Health Sciences Centre, Department of Pathology and Laboratory Medicine, London, ON N6A 5A5, Canada.
Patrick LukeMatthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON N6A 5A5, Canada.
Alp SenerDepartment of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada.
London Health Sciences Centre · CAWestern University · CARobarts Clinical Trials · CAUniversity of Ghana · GH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kidney transplantation is preferred for end-stage renal disease. The current gold standard for kidney preservation is static cold storage (SCS) at 4 °C. However, SCS contributes to renal graft damage through ischemia-reperfusion injury (IRI). We previously reported renal graft protection after SCS with a hydrogen sulfide donor, sodium thiosulfate (STS), at 4 °C. Therefore, this study aims to investigate whether SCS at 10 °C with STS and Hemopure (blood substitute), will provide similar protection. Using in vitro model of IRI, we subjected rat renal proximal tubular epithelial cells to hypoxia-reoxygenation for 24 h at 10 °C with or without STS and measured cell viability. In vivo, we preserved 36 donor kidneys of Lewis rats for 24 h in a preservation solution at 10 °C supplemented with STS, Hemopure, or both followed by transplantation. Tissue damage and recipient graft function parameters, including serum creatinine, blood urea nitrogen, urine osmolality, and glomerular filtration rate (GFR), were evaluated. STS-treated proximal tubular epithelial cells exhibited enhanced viability at 10 °C compared with untreated control cells (

Indexed as

HemoglobinsKidney TransplantationReperfusion InjuryThiosulfatesAnimalsGraft SurvivalKidneyOrgan PreservationRatsRats, Inbred LewHBOC 201Hemoglobinssodium thiosulfateThiosulfatesgraft and recipient survivalHemopureischemia–reperfusion injury (IRI)kidney transplantationsodium thiosulfate (STS)static cold storage (SCS)

Identifiers

PMID38396887
PMCPMC10889495
OpenAlexW4391744233

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.