Evidence map›Paper›PMID 38396859›Full record

ArticleInternational journal of molecular sciences2024

Platinum(IV) Prodrugs Incorporating an Indole-Based Derivative, 5-Benzyloxyindole-3-Acetic Acid in the Axial Position Exhibit Prominent Anticancer Activity.

Angelico D Aputen, Maria George Elias, Jayne Gilbert, Jennette A Sakoff, Christopher P Gordon, Kieran F Scott, Janice R Aldrich-Wright

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. "Non-Classical" Platinum Complexes: A Concise Review.International journal of molecular sciences · 2025
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Angelico D AputenSchool of Science, Western Sydney University, Sydney, NSW 2751, Australia.ORCID 0000-0002-5560-9724
Maria George EliasSchool of Science, Western Sydney University, Sydney, NSW 2751, Australia.
Jayne GilbertCalvary Mater Newcastle Hospital, Newcastle, NSW 2298, Australia.ORCID 0000-0001-5034-386X
Jennette A SakoffCalvary Mater Newcastle Hospital, Newcastle, NSW 2298, Australia.ORCID 0000-0002-7009-5792
Christopher P GordonSchool of Science, Western Sydney University, Sydney, NSW 2751, Australia.ORCID 0000-0001-7583-5609
Kieran F ScottIngham Institute, Sydney, NSW 2170, Australia.ORCID 0000-0002-6012-4107
Janice R Aldrich-WrightSchool of Science, Western Sydney University, Sydney, NSW 2751, Australia.ORCID 0000-0002-6943-6908
Western Sydney University · AUCalvary Mater Newcastle Hospital · AUIngham Institute · AU

Funding

Australian Government Research Training Program Scholarship Not applicable
6 · The paper itself

Abstract

Kinetically inert platinum(IV) complexes are a chemical strategy to overcome the impediments of standard platinum(II) antineoplastic drugs like cisplatin, oxaliplatin and carboplatin. In this study, we reported the syntheses and structural characterisation of three platinum(IV) complexes that incorporate 5-benzyloxyindole-3-acetic acid, a bioactive ligand that integrates an indole pharmacophore. The purity and chemical structures of the resultant complexes,

Indexed as

Antineoplastic AgentsProdrugsCarboplatinCell Line, TumorCisplatinHumansHydroxyindoleacetic AcidOxaliplatinPlatinum5-benzyloxyindole-3-acetic acidAntineoplastic AgentsCarboplatinCisplatinHydroxyindoleacetic AcidOxaliplatinPlatinumProdrugs56MESSchemotherapycisplatincytotoxicityHDACmitochondriaplatinum(II)platinum(IV)ROS

Identifiers

PMID38396859
PMCPMC10888562
OpenAlexW4391747803

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.