ReviewInternational journal of molecular sciences2024
The Role of Interleukin 6 in Periodontitis and Its Complications.
Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 7 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Effect of Vaping on Treatment Outcomes in Patients With Gingivitis, Periodontitis, and/or Peri-Implant Disease: A Systematic Review.Clinical and experimental dental research · 2026Pooled it
- Impact of Endodontic Treatment of Teeth With Apical Periodontitis on Levels of Inflammatory Biomarkers Associated With Cardiovascular Risk: A Systematic Review and Meta-Analysis.TheScientificWorldJournal · 2026Pooled it
- Inflammatory Association between Periodontal Disease and Systemic Health.Inflammation · 2025Pooled it
- Effects of Periodontal Therapy on Cardiovascular Risk Biomarkers: A Systematic Review.Oral health & preventive dentistry · 2025Pooled it
- Relationship Between MCP-1 Levels in GCF and Periodontitis: A Systematic Review With Meta-Analysis and Analysis of Molecular Interactions.Journal of cellular and molecular medicine · 2025Pooled it
- The impact of scaling and root planning combined with mouthwash during pregnancy on preterm birth and low birth weight: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2024Pooled it
- Cytokines profile in gingival crevicular fluid of subjects wearing fixed dental prostheses: a systematic review and meta-analysis.European journal of medical research · 2024Pooled it
- Three-session non-surgical therapy stabilizes microbiological and biochemical responses in patients with stage III/IV grade C periodontitis: a randomized clinical trial.Clinical oral investigations · 2025Trial
- A case of suspected neurofibromatosis type 1 in monozygotic 13-year-old twins with submucosal cleft palate.Radiology case reports · 2026Article
- CB2 Receptor Activation Attenuates IL-1β-Induced Inflammatory Transcriptomic Networks in Human Gingival Fibroblasts.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Interleukin-6 as an Oral-Vascular Inflammatory Bridge: Integrating CXCL10 and Haptoglobin 2-2 into a Potential Model of Periodontitis-Associated Cardiovascular Risk.International journal of molecular sciences · 2026Review
- Dual therapeutic potential of bacteriocin Basin from Bacillus halophilus: attenuation of Enterococcus faecalis virulence gene expression and cytotoxic activity against KB (HeLa-Derived) cells.Molecular biology reports · 2026Article
- Ferulic Acid Modulates High Glucose-Induced MMP-1/TIMP-1 Imbalance and Enhances Wound Closure of Human Gingival Fibroblasts.Biomedicines · 2026Article
- IL-6/STAT3-Mediated miR-181a-5p in Bone Marrow-Derived Mesenchymal Stem Cells Regulates Th17/Treg Balance in Experimental Periodontitis.International dental journal · 2026Article
- Dysregulated calcium signaling underlies hyposalivation and microbial dysbiosis in Down syndrome.Cell reports · 2026Article
- Salivary Cytokine Profiles in Active Smokers: An Exploratory Cross-Sectional Study of IL-2, IL-6, and IL-8.Diagnostics (Basel, Switzerland) · 2026Article
- Association of menopausal status and genetic polymorphisms with early crestal bone loss around dental implants: A prospective observational study.Journal of Indian Prosthodontic Society · 2026Observational
- Phytosphingosine disrupts dual-species oral biofilms and attenuates LPS-induced pro-inflammatory responses in human gingival fibroblasts.Scientific reports · 2026Article
- Effect of Melatonin as an Adjunct to NSPT on Periodontal and Systemic Outcomes in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of RCTs.Journal of clinical medicine · 2026Review
- Micro/Nanoplastics and Periodontitis: An Environmental Microbiology Perspective on Oral Retention and Systemic Risk.Microorganisms · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interleukin 6 (IL-6) is a pleomorphic pro-inflammatory cytokine that is strongly associated with local as well as systemic inflammatory processes. Its role in physiological and pathogenic processes throughout the human body has been the subject of numerous studies in recent years. Measurements of the IL-6 levels in gingival crevicular fluid (GFC), as well as in serum, can be important diagnostic and prognostic factors in periodontal diseases (PD) and in assessing their impact on a range of related inflammatory diseases. This narrative review explores the significant role of IL-6 in patients with periodontitis and its association with other widespread inflammatory pathologies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.