Effect of Low-Frequency Renal Nerve Stimulation on Renal Glucose Release during Normoglycemia and a Hypoglycemic Clamp in Pigs.

Marius Nistor, Martin Schmidt, Carsten Klingner, Caroline Klingner, Georg Matziolis, Sascha Shayganfar, René Schiffner

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Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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7 authors.

Marius NistorOrthopaedic Department, Jena University Hospital, 07747 Jena, Germany.ORCID 0000-0003-4733-8503

Martin SchmidtInstitute for Biochemistry II, Jena University Hospital, 07747 Jena, Germany.ORCID 0000-0003-3578-4338

Carsten KlingnerDepartment of Neurology, Jena University Hospital, 07747 Jena, Germany.ORCID 0000-0001-8815-3391

Caroline KlingnerDepartment of Neurology, Jena University Hospital, 07747 Jena, Germany.

Georg MatziolisOrthopaedic Department, Jena University Hospital, 07747 Jena, Germany.

Sascha ShayganfarEmergency Department, Helios University Clinic Wuppertal, 42283 Wuppertal, Germany.

René SchiffnerOrthopaedic Department, Jena University Hospital, 07747 Jena, Germany.ORCID 0009-0001-0475-5844

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previously, we demonstrated that renal denervation in pigs reduces renal glucose release during a hypoglycemic episode. In this study we set out to examine changes in side-dependent renal net glucose release (SGN) through unilateral low-frequency stimulation (LFS) of the renal plexus with a pulse generator (2-5 Hz) during normoglycemia (60 min) and insulin-induced hypoglycemia ≤3.5 mmol/L (75 min) in seven pigs. The jugular vein, carotid artery, renal artery and vein, and both ureters were catheterized for measurement purposes, blood pressure management, and drug and fluid infusions. Para-aminohippurate (PAH) and inulin infusions were used to determine side-dependent renal plasma flow (SRP) and glomerular filtration rate (GFR). In a linear mixed model, LFS caused no change in SRP but decreased sodium excretion (

Indexed as

GlucoseHypoglycemiaAnimalsBlood GlucoseGlomerular Filtration RateHypoglycemic AgentsKidneySodiumSwineBlood GlucoseGlucoseHypoglycemic AgentsSodiumdiabetes mellitusglucose metabolismhypoglycemialow-frequency renal nerve stimulation

Identifiers

PMID38396718

DOI10.3390/ijms25042041

PMCPMC10888375

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