Evidence map›Paper›PMID 38396697›Full record

ReviewInternational journal of molecular sciences2024

Understanding Type 3 Innate Lymphoid Cells and Crosstalk with the Microbiota: A Skin Connection.

Thao Tam To, Nicole Chizara Oparaugo, Alexander R Kheshvadjian, Amanda M Nelson, George W Agak

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Memory Cells in Atopic Dermatitis: Paving the Way to Disease Modification.International journal of molecular sciences · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Thao Tam ToDivision of Dermatology, Department of Medicine, University of California (UCLA), Los Angeles, CA 90095, USA.ORCID 0000-0001-7630-0913
Nicole Chizara OparaugoDivision of Dermatology, Department of Medicine, University of California (UCLA), Los Angeles, CA 90095, USA.
Alexander R KheshvadjianDivision of Dermatology, Department of Medicine, University of California (UCLA), Los Angeles, CA 90095, USA.
Amanda M NelsonDepartment of Dermatology, Penn State University College of Medicine, Hershey, PA 17033, USA.
George W AgakDivision of Dermatology, Department of Medicine, University of California (UCLA), Los Angeles, CA 90095, USA.ORCID 0000-0002-3356-9864
University of California, Los Angeles · USPennsylvania State University · US

Funding

The Role of T cell Extracellular Traps in Acne PathogenesisR01AR081337 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI George W Agak · 2022 to 2026
$2.2M
NIH HHS R01AR081337
6 · The paper itself

Abstract

Innate lymphoid cells (ILCs) are a diverse population of lymphocytes classified into natural killer (NK) cells, ILC1s, ILC2s, ILC3s, and ILCregs, broadly following the cytokine secretion and transcription factor profiles of classical T cell subsets. Nonetheless, the ILC lineage does not have rearranged antigen-specific receptors and possesses distinct characteristics. ILCs are found in barrier tissues such as the skin, lungs, and intestines, where they play a role between acquired immune cells and myeloid cells. Within the skin, ILCs are activated by the microbiota and, in turn, may influence the microbiome composition and modulate immune function through cytokine secretion or direct cellular interactions. In particular, ILC3s provide epithelial protection against extracellular bacteria. However, the mechanism by which these cells modulate skin health and homeostasis in response to microbiome changes is unclear. To better understand how ILC3s function against microbiota perturbations in the skin, we propose a role for these cells in response to

Indexed as

LymphocytesMicrobiotaCytokinesImmunity, InnateKiller Cells, NaturalSkinCytokinesacne vulgarisCutibacterium acnesILC3sILCsinnate lymphoid cellsmicrobiomeskin diseasesskin microbiomeskin microbiotatype 3 innate lymphoid cells

Identifiers

PMID38396697
PMCPMC10888374
OpenAlexW4391614007

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.