Evidence map›Paper›PMID 38396427›Full record

ReviewDiagnostics (Basel, Switzerland)2024

The Use of Artificial Intelligence in the Liver Histopathology Field: A Systematic Review.

Flavia Grignaffini, Francesco Barbuto, Maurizio Troiano, Lorenzo Piazzo, Patrizio Simeoni, Fabio Mangini, Cristiano De Stefanis, Andrea Onetti Muda, Fabrizio Frezza, Anna Alisi

Open access · goldAbstract readReview
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Flavia GrignaffiniDepartment of Information Engineering, Electronics and Telecommunications (DIET), "La Sapienza", University of Rome, 00184 Rome, Italy.
Francesco BarbutoDepartment of Information Engineering, Electronics and Telecommunications (DIET), "La Sapienza", University of Rome, 00184 Rome, Italy.
Maurizio TroianoResearch Unit of Genetics of Complex Phenotypes, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Lorenzo PiazzoDepartment of Information Engineering, Electronics and Telecommunications (DIET), "La Sapienza", University of Rome, 00184 Rome, Italy.ORCID 0000-0002-5325-8561
Patrizio SimeoniNational Transport Authority (NTA), D02 WT20 Dublin, Ireland.
Fabio ManginiDepartment of Information Engineering, Electronics and Telecommunications (DIET), "La Sapienza", University of Rome, 00184 Rome, Italy.ORCID 0000-0001-5474-8952
Cristiano De StefanisResearch Unit of Genetics of Complex Phenotypes, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.ORCID 0000-0001-5898-9518
Andrea Onetti MudaBambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.ORCID 0000-0002-0274-6178
Fabrizio FrezzaDepartment of Information Engineering, Electronics and Telecommunications (DIET), "La Sapienza", University of Rome, 00184 Rome, Italy.ORCID 0000-0001-9457-7617
Anna AlisiResearch Unit of Genetics of Complex Phenotypes, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.ORCID 0000-0001-7241-6329
Sapienza University of Rome · ITBambino Gesù Children's Hospital · ITNational Disability Authority · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Digital pathology (DP) has begun to play a key role in the evaluation of liver specimens. Recent studies have shown that a workflow that combines DP and artificial intelligence (AI) applied to histopathology has potential value in supporting the diagnosis, treatment evaluation, and prognosis prediction of liver diseases. Here, we provide a systematic review of the use of this workflow in the field of hepatology. Based on the PRISMA 2020 criteria, a search of the PubMed, SCOPUS, and Embase electronic databases was conducted, applying inclusion/exclusion filters. The articles were evaluated by two independent reviewers, who extracted the specifications and objectives of each study, the AI tools used, and the results obtained. From the 266 initial records identified, 25 eligible studies were selected, mainly conducted on human liver tissues. Most of the studies were performed using whole-slide imaging systems for imaging acquisition and applying different machine learning and deep learning methods for image pre-processing, segmentation, feature extractions, and classification. Of note, most of the studies selected demonstrated good performance as classifiers of liver histological images compared to pathologist annotations. Promising results to date bode well for the not-too-distant inclusion of these techniques in clinical practice.

Indexed as

artificial intelligencebiopsycomputer-aided diagnosticsconvolutional neural networksdeep learninghistological imageshistologylivermachine learning

Identifiers

PMID38396427
PMCPMC10887838
OpenAlexW4391747279

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.