Evidence map›Paper›PMID 38396206›Full record

ArticleEMBO reports2024

TORC1 is an essential regulator of nutrient-controlled proliferation and differentiation in Leishmania.

Elmarie Myburgh, Vincent Geoghegan, Eliza Vc Alves-Ferreira, Y Romina Nievas, Jaspreet S Grewal, Elaine Brown, Karen McLuskey, Jeremy C Mottram

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EMBO reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Elmarie MyburghYork Biomedical Research Institute, Hull York Medical School, University of York, York, YO10 5DD, UK. elmarie.myburgh@york.ac.uk.ORCID 0000-0002-2007-5902
Vincent GeogheganYork Biomedical Research Institute, Department of Biology, University of York, York, YO10 5DD, UK.ORCID 0000-0001-5893-607X
Eliza Vc Alves-FerreiraYork Biomedical Research Institute, Department of Biology, University of York, York, YO10 5DD, UK.
Y Romina NievasYork Biomedical Research Institute, Department of Biology, University of York, York, YO10 5DD, UK.ORCID 0000-0002-1690-259X
Jaspreet S GrewalYork Biomedical Research Institute, Department of Biology, University of York, York, YO10 5DD, UK.
Elaine BrownYork Biomedical Research Institute, Department of Biology, University of York, York, YO10 5DD, UK.
Karen McLuskeyWellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK.ORCID 0000-0002-9841-4943
Jeremy C MottramYork Biomedical Research Institute, Department of Biology, University of York, York, YO10 5DD, UK.ORCID 0000-0001-6204-0460
University of York · GBWellcome Centre for Molecular Parasitology · GB

Funding

Resource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2M
Medical Research Council MR/K019384/1NIGMS NIH HHS P41 GM103311Wellcome TrustWellcome Trust 200807
6 · The paper itself

Abstract

Leishmania parasites undergo differentiation between various proliferating and non-dividing forms to adapt to changing host environments. The mechanisms that link environmental cues with the parasite's developmental changes remain elusive. Here, we report that Leishmania TORC1 is a key environmental sensor for parasite proliferation and differentiation in the sand fly-stage promastigotes and for replication of mammalian-stage amastigotes. We show that Leishmania RPTOR1, interacts with TOR1 and LST8, and identify new parasite-specific proteins that interact in this complex. We investigate TORC1 function by conditional deletion of RPTOR1, where under nutrient-rich conditions RPTOR1 depletion results in decreased protein synthesis and growth, G1 cell cycle arrest and premature differentiation from proliferative promastigotes to non-dividing mammalian-infective metacyclic forms. These parasites are unable to respond to nutrients to differentiate into proliferative retroleptomonads, which are required for their blood-meal induced amplification in sand flies and enhanced mammalian infectivity. We additionally show that RPTOR1

Indexed as

LeishmaniaPhlebotomusPsychodidaeAnimalsCell ProliferationMammalsNutrientsNutrientsDifferentiationLeishmaniaProliferationRPTOR1TORC1

Identifiers

PMID38396206
PMCPMC10933368
OpenAlexW4392111279

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.