ArticleScientific reports2024
Blood urea nitrogen to albumin ratio is associated with cerebral small vessel diseases.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 10 citations in OpenAlex.
- Association between the blood urea nitrogen to albumin ratio and all-cause mortality in critically ill patients with liver cirrhosis.BMC gastroenterology · 2026Article
- Association of the Albumin-Bilirubin score with 7-day incident delirium risk following bloodstream infection in critically ill adults: evidence from a propensity-weighted cohort.BMC infectious diseases · 2026Article
- Predicting stroke-associated infection in acute ischemic stroke patients treated by thrombolysis.Frontiers in cellular neuroscience · 2026Article
- The Prognostic Value of Biomarkers in Patients Diagnosed with Spontaneous Bacterial Peritonitis.Journal of clinical medicine · 2025Article
- Association of blood urea nitrogen to serum albumin ratio with arterial stiffness in type 2 diabetes patients: a Chinese cross-sectional study.Frontiers in endocrinology · 2025Article
- The relationship between erectile dysfunction and blood urea nitrogen/creatinine and blood urea nitrogen/albumin ratios: A case-control study.Central European journal of urology · 2025Article
- The association between blood urea nitrogen to albumin ratio and cognitive function in Parkinson's disease patients.Frontiers in neurology · 2025Article
- Effects of grape pomace on growth performance, serum biochemical indices, amino acid composition, and rumen microbial diversity in Dorper × Hu hybrid sheep.Frontiers in veterinary science · 2025Article
- Exploring the value of blood urea nitrogen-to-albumin ratio in patients with acute pancreatitis admitted to the intensive care unit: a retrospective cohort study.Frontiers in nutrition · 2025Article
- Association Between Blood Urea Nitrogen/Albumin and the Incidence as Well as Progression of Type 2 Diabetes.Nutrients · 2024Article
- Association of blood urea nitrogen to albumin ratio with cerebral small vessel disease and its ischemic imaging markers: a cross-sectional study.Frontiers in neurologyArticle
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Blood urea nitrogen (BUN) to albumin ratio (BAR) is a comprehensive parameter that reflects renal, inflammatory, nutritional, and endothelial functions. BAR has been shown to be associated with various cancers, pneumonia, sepsis, and pulmonary and cardiovascular diseases; however, few studies have been conducted on its association with cerebrovascular diseases. In this study, we evaluated the association between BAR and cerebral small vessel disease (cSVD) in health check-up participants. We assessed consecutive health check-up participants between January 2006 and December 2013. For the cSVD subtype, we quantitatively measured the volume of white matter hyperintensity (WMH) and qualitatively measured the presence of lacune and cerebral microbleeds (CMBs). The BAR was calculated by dividing BUN by albumin as follows: BAR = BUN (mg/dl)/albumin (g/dl). A total of 3012 participants were evaluated. In multivariable linear regression analysis, BAR showed a statistically significant association with WMH volume after adjusting for confounders [β = 0.076, 95% confidence interval (CI): 0.027-0.125]. In multivariable logistic regression analyses, BAR was significantly associated with lacunes [adjusted odds ratio (aOR) = 1.20, 95% CI: 1.00-1.44] and CMBs (aOR = 1.28, 95% CI: 1.06-1.55). BAR was associated with all types of cSVD in the health check-up participants.
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