Evidence map›Paper›PMID 38396136›Full record

ArticleScientific reports2024

Kidney double positive T cells have distinct characteristics in normal and diseased kidneys.

Sanjeev Noel, Andrea Newman-Rivera, Kyungho Lee, Sepideh Gharaie, Shishir Patel, Nirmish Singla, Hamid Rabb

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Functionally heterogeneous intratumoral CD4Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sanjeev NoelDepartment of Medicine, Johns Hopkins University, Ross 970, 720 Rutland Avenue, Baltimore, MD, 21205, USA. snoel6@jhmi.edu.
Andrea Newman-RiveraDepartment of Medicine, Johns Hopkins University, Ross 970, 720 Rutland Avenue, Baltimore, MD, 21205, USA.
Kyungho LeeDepartment of Medicine, Johns Hopkins University, Ross 970, 720 Rutland Avenue, Baltimore, MD, 21205, USA.
Sepideh GharaieDepartment of Medicine, Johns Hopkins University, Ross 970, 720 Rutland Avenue, Baltimore, MD, 21205, USA.
Shishir PatelDepartment of Medicine, Johns Hopkins University, Ross 970, 720 Rutland Avenue, Baltimore, MD, 21205, USA.
Nirmish SinglaDepartment of Urology, Johns Hopkins University, Baltimore, MD, USA.
Hamid RabbDepartment of Medicine, Johns Hopkins University, Ross 970, 720 Rutland Avenue, Baltimore, MD, 21205, USA.
Johns Hopkins University · US

Funding

Acute Kidney Injury and Double Negative T CellsR01DK104662 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI HAMAD, ABDEL RAHIM, RABB, HAMID · 2015 to 2023
$3.8M
Acute kidney injury and microbiomeR01DK123342 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI RABB, HAMID · 2020 to 2024
$3.0M
TIGIT in acute kidney injury and repairR01DK132278 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI Sanjeev Noel · 2023 to 2026
$1.9M
Cytek Aurora full spectrum flow cytometric analyzerS10OD026859 · OD · JOHNS HOPKINS UNIVERSITY · PI WANG, ZACK Z. · 2019 to 2019
$242k
NIDDK NIH HHS R01 DK104662NIDDK NIH HHS R01DK104662NIDDK NIH HHS R01 DK123342NIDDK NIH HHS R01DK123342NIDDK NIH HHS R01 DK132278NIDDK NIH HHS R01DK132278NIH HHS S10 OD026859
6 · The paper itself

Abstract

Multiple types of T cells have been described and assigned pathophysiologic functions in the kidneys. However, the existence and functions of TCR+CD4+CD8+ (double positive; DP) T cells are understudied in normal and diseased murine and human kidneys. We studied kidney DPT cells in mice at baseline and after ischemia reperfusion (IR) and cisplatin injury. Additionally, effects of viral infection and gut microbiota were studied. Human kidneys from patients with renal cell carcinoma were evaluated. Our results demonstrate that DPT cells expressing CD4 and CD8 co-receptors constitute a minor T cell population in mouse kidneys. DPT cells had significant Ki67 and PD1 expression, effector/central memory phenotype, proinflammatory cytokine (IFNγ, TNFα and IL-17) and metabolic marker (GLUT1, HKII, CPT1a and pS6) expression at baseline. IR, cisplatin and viral infection elevated DPT cell proportions, and induced distinct functional and metabolic changes. scRNA-seq analysis showed increased expression of Klf2 and Ccr7 and enrichment of TNFα and oxidative phosphorylation related genes in DPT cells. DPT cells constituted a minor population in both normal and cancer portion of human kidneys. In conclusion, DPT cells constitute a small population of mouse and human kidney T cells with distinct inflammatory and metabolic profile at baseline and following kidney injury.

Indexed as

T-LymphocytesVirus DiseasesAnimalsCisplatinHumansIschemiaKidneyMiceTumor Necrosis Factor-alphaCisplatinTumor Necrosis Factor-alphaAKICisplatinDouble positive T cellsDPT cellsIschemia reperfusion

Identifiers

PMID38396136
PMCPMC10891070
OpenAlexW4392095706

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.